Recent applications of organic molecule-based framework porous materials in solid-phase microextraction for...

Area of Science:

• Analytical Chemistry
• Materials Science

Background:

• Sample preparation is crucial for analyzing complex pharmaceutical samples.
• Solid-phase microextraction (SPME) is favored for its efficiency, reduced solvent use, and automation capabilities.
• Novel sorbent materials are key to enhancing SPME selectivity and extraction efficiency.

Purpose of the Study:

• To review recent applications of organic molecule-based framework porous materials in SPME.
• To focus on the use of Metal-Organic Frameworks (MOFs) and Covalent Organic Frameworks (COFs) as SPME coating materials.
• To discuss their application in pharmaceutical analysis across food, environmental, and biological matrices.

Main Methods:

• Review of literature on organic porous materials used as SPME sorbents.
• Discussion of four SPME device types: on-fiber, in-tube, thin film, and stir bar.
• Exploration of other organic porous materials like Hypercrosslinked Polymers (HCPs) and Conjugated Microporous Polymers (CMPs).

Main Results:

• MOFs and COFs show significant promise as SPME sorbent materials.
• These materials enable selective and efficient extraction of analytes in complex samples.
• Various SPME formats are effectively utilizing these advanced porous materials.

Conclusions:

• Organic molecule-based framework porous materials are highly effective for SPME in pharmaceutical analysis.
• Continued research into MOFs, COFs, HCPs, and CMPs will advance SPME technology.
• These materials offer a promising future for sensitive and efficient sample preparation.