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Alkyl polyglucoside-based supramolecular solvent formation in liquid-phase microextraction.

Christina Vakh¹, Svetlana Kasper¹, Yanina Kovalchuk¹

¹Institute of Chemistry, Saint-Petersburg University St.Petersburg State University, SPbSU, SPbU, 7/9 Universitetskaya nab., St. Petersburg, 199034, Russia.

Analytica Chimica Acta

|September 20, 2022

Summary

Researchers developed novel alkyl polyglucoside-based supramolecular solvents for green microextraction. These solvents efficiently separate epinephrine from urine, offering a promising, eco-friendly analytical method.

Keywords:

Alkyl carboxylic acid Alkyl polyglucoside Epinephrine (adrenaline)Liquid chromatography Supramolecular solvent Urine

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Characteristics of Precipitation-formed Polyethylene Glycol Microgels Are Controlled by Molecular Weight of Reactants

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Published on: December 23, 2013

Area of Science:

Supramolecular Chemistry
Analytical Chemistry
Green Chemistry

Background:

Alkyl polyglucosides (APGs) are nonionic surfactants with potential for novel applications.
Supramolecular solvents offer unique properties for separation science.
Coacervation is a liquid-liquid phase separation process driven by molecular interactions.

Purpose of the Study:

To describe the formation of APG-based supramolecular solvents using alkyl carboxylic acids.
To investigate the physico-chemical properties of these novel solvents.
To develop and apply a green microextraction method for epinephrine analysis.

Main Methods:

Studied various APGs and carboxylic acids as amphiphiles and coacervation agents.
Investigated the mechanism and properties of APG-based supramolecular solvents.
Developed a liquid-phase microextraction (LPME) method using the supramolecular solvent for epinephrine extraction from urine.
Analyzed epinephrine using high-performance liquid chromatography with fluorometric detection.

Main Results:

Successfully formed APG-based supramolecular solvents for the first time.
Identified caprylyl/capryl glucoside as the most effective precursor for epinephrine microextraction (95% recovery).
Demonstrated efficient separation and preconcentration of epinephrine from human urine.
Showcased the utility of cooling-induced decantation for extract phase collection.
Characterized the developed solvents as less viscous and more HPLC-compatible than traditional nonionic surfactant-based solvents.

Conclusions:

APG-based supramolecular solvents represent a novel and green alternative for microextraction.
The developed method provides an efficient approach for epinephrine determination in biological samples.
The reduced viscosity and enhanced compatibility make these solvents suitable for advanced chromatographic techniques.