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Association of advanced paternal age with lung function at school age
Chun-Chun Gau1,2,3,4, Hsin-Ju Lee1, Hung-Yi Lu1
1Division of Allergy, Asthma, and Rheumatology, Department of Pediatrics, Chang Gung Memorial Hospital, 5 Fu-Hsin Street, Kweishan, Taoyuan, Taiwan.
Respiratory Research
|September 20, 2022
Summary
Advanced paternal age is linked to reduced lung function in children, particularly those exposed to environmental tobacco smoke or not breastfed. This highlights a novel adverse effect of paternal age on respiratory health.
Area of Science:
- Pediatric Respiratory Health
- Reproductive Epidemiology
- Childhood Lung Function
Background:
- Epidemiological studies suggest advanced paternal age impacts offspring health.
- The specific effects on children's respiratory health remain unclear.
Purpose of the Study:
- To investigate the association between paternal age and lung function in children.
- To examine the relationship between paternal age and fraction of exhaled nitric oxide (FeNO).
Main Methods:
- Analysis of data from 1330 children (mean age 6.4 years) from the LIGHTS cohort.
- Measurements included lung function and FeNO.
- Covariate-adjusted regression analyses were applied.
Main Results:
- Increased paternal age was associated with decreased FEV1/FVC ratio and FEF75.
- These associations were significant among children with prenatal exposure to environmental tobacco smoke (ETS) or those not breastfed.
- No association was found between paternal age and FeNO.
Conclusions:
- Advanced paternal age is linked to reduced lung function in school-aged children.
- Children exposed to ETS prenatally or not breastfed are more vulnerable.
- Further research is needed to confirm these findings.
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