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Destructive spondylodiscitis associated with SAPHO syndrome: A case report and literature review
Shu Takeuchi1, Junya Hanakita1, Toshiyuki Takahashi1
1Spinal Disorders Center, Fujieda Heisei Memorial Hospital, Mizukami, Fujieda, Japan.
Background:
Synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome is a rare sterile inflammatory disease characterized by cutaneous and osteoarticular lesions. Associated spinal lesions chronically manifest slight or no neurological symptoms. Only rarely does destructive spondylodiscitis occur.
Case Description:
A 62-year-old female with palmoplantar pustulosis presented with a rapidly progressive quadriparesis. When the cervical MR showed destructive spondylodiscitis at the C5-C7 level, the patient underwent anterior debridement followed by posterior reconstruction/fixation. The histopathology showed a nonspecific inflammatory process with vertebral sclerosis consistent with the diagnosis of SAPHO; cultures were negative. Postoperatively, the patient's symptoms improved and SAPHO did not recur.
Conclusion:
Destructive spondylodiscitis associated with SAPHO syndrome is uncommon. Early diagnosis and surgical treatment result in the best outcomes.
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