The role of claudin-6 in chromophobe renal cell carcinoma
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Updated: Aug 28, 2025

Comparing Metastatic Clear Cell Renal Cell Carcinoma Model Established in Mouse Kidney and on Chicken Chorioallantoic Membrane
Published on: February 8, 2020
Franziska Erlmeier1, Stefanie Zschäbitz2, Marie Mikuteit3
1Institute of Pathology, University Hospital of Erlangen, Erlangen, Germany. f.erlmeier@icloud.com.
Background:
The prognostic value of Claudin-6 (CLDN6) in non clear cell renal cell carcinoma (RCC) is still unclear.
Aim:
To evaluate the prognostic impact of CLDN6 expression in a large cohort of chromophobe RCC (chRCC).
Material And Methods:
Patients who underwent renal surgery due to chRCC were recruited. Clinical data were retrospectively evaluated. Tumor specimens were analyzed for CLDN6 expression by immunohistochemistry.
Results:
81 chRCC patients were eligible for analysis, thereof 10 (12.3%) patients were positive for CLDN6. No significant associations were found for CLDN6 expression and clinical attributes in patients with chRCC. Kaplan-Meier analysis revealed no differences in overall survival (OS) for patients with CLDN6⁻ compared to CLDN6⁺ tumors (87.0% versus 62.5%; p=0.174).
Conclusion:
In chRCC CLDN6 expression is not associated with parameters of aggressiveness or survival. Due to the rare incidence of chRCC further studies with larger cohorts are warranted.
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