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Related Concept Videos

Imaging Studies II: Ultrasonography01:24

Imaging Studies II: Ultrasonography

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IntroductionUltrasonography, or renal ultrasound, is a noninvasive medical imaging technique that uses high-frequency sound waves to visualize the kidneys, ureters, bladder, and surrounding tissues.Indications for Urinary System UltrasonographyUrinary system ultrasonography is indicated in various clinical scenarios, such as:Kidney Stones (Urolithiasis): To detect and monitor the size and presence of kidney or urinary tract stones.Hydronephrosis: To assess the dilation of the renal pelvis and...
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Imaging Studies VI: Voiding Cystourethrography and Cystography01:22

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Voiding Cystourethrography (VCUG) and Cystography are specialized radiographic procedures used to examine the structure and function of the bladder and urethra.Voiding Cystourethrography (VCUG)A Voiding Cystourethrogram (VCUG) is a diagnostic imaging procedure that assesses the anatomy and function of the lower urinary tract. It focuses on the bladder, bladder neck, and urethra, helping detect abnormalities such as vesicoureteral reflux (VUR)—the backward or reverse flow of urine into the...
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Lensless On-chip Imaging of Cells Provides a New Tool for High-throughput Cell-Biology and Medical Diagnostics
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Lens Free Holographic Imaging for Urinary Tract Infection Screening.

Gregory N McKay, Anisha Oommen, Carolina Pacheco

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    |September 21, 2022
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    Summary
    This summary is machine-generated.

    Holographic lens-free imaging (LFI) enables point-of-care urine analysis for urinary tract infections (UTIs). This technology detects key biomarkers like blood cells and bacteria, offering rapid, accurate bedside diagnostics.

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    Area of Science:

    • Biomedical Optics
    • Point-of-Care Diagnostics
    • Medical Imaging

    Background:

    • Current urinary tract infection (UTI) diagnosis requires complex laboratory procedures.
    • Point-of-care diagnostics are needed for rapid UTI detection.

    Purpose of the Study:

    • To investigate holographic lens-free imaging (LFI) for automated, bedside urine analysis.
    • To assess LFI's capability in detecting UTI-related biomarkers.

    Main Methods:

    • Developed an LFI system for urine analysis.
    • Utilized LFI to resolve red blood cells, white blood cells, crystals, and casts in urine phantoms.
    • Correlated LFI measurements with hemacytometer counts for accuracy.

    Main Results:

    • LFI accurately detects clinically relevant concentrations of bacteria and blood cells.
    • Demonstrated high correlation (R² > 0.99) with ground truth measurements for hematuria and pyuria.
    • Successfully differentiated between UTI-positive and UTI-negative human urine samples.

    Conclusions:

    • LFI shows significant promise for sensitive, point-of-care urine screening.
    • This technology can facilitate early detection of UTIs and other pathological processes at the bedside.