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Updated: Aug 28, 2025

Light-driven Enzymatic Decarboxylation
Published on: May 22, 2016
Visible-Light-Promoted Carbene Insertion and Decarbonylation for the Synthesis of α-Substituted γ-Ketoesters
Weina Li1, Yingying Yang1, Zhiliang Tang1
1Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, Yunnan Provincial Center for Research & Development of Natural Products, and School of Pharmacy, Yunnan University, Kunming 650500, P. R. China.
Abstract:
Herein, we report a blue visible-light-promoted approach for preparing a variety of α-substituted γ-ketoester derivatives through carbene insertion and the decarbonylation of enaminones and diazoesters. These reactions use readily available starting materials and transition-metal-free, eco-friendly procedures that are amenable to gram-scale synthesis and wide functional group tolerance. This methodology may be useful for constructing polysubstituted heterocycles with potential biological activity.
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