Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Overview of Carbohydrate Metabolism01:19

Overview of Carbohydrate Metabolism

1.5K
Carbohydrate metabolism is a fundamental biochemical process that ensures a constant supply of energy to living cells. The most important carbohydrate is glucose, which can be broken down via glycolysis to enter into the Krebs cycle and eventually lead to the production of ATP through oxidative phosphorylation.
Glucose transport into cells is facilitated by a family of transport proteins called GLUT (Glucose Transporters). GLUT4 is the primary glucose transporter for insulin-stimulated glucose...
1.5K
Fats as Energy Storage Molecules01:06

Fats as Energy Storage Molecules

25.6K
Triglycerides are a form of long-term energy storage molecules. They are made of glycerol and three fatty acids. To obtain energy from fat, triglycerides must first be broken down by hydrolysis into their two principal components, fatty acids and glycerol. This process, called lipolysis, takes place in the cytoplasm. The resulting fatty acids are oxidized by β-oxidation into acetyl-CoA, which is used by the Krebs cycle. The glycerol that is released from triglycerides after lipolysis...
25.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Characteristics and time course of postconcussive symptoms in children and adolescents with moderate to severe extracranial trauma with and without mild traumatic brain injury.

The journal of trauma and acute care surgery·2026
Same author

Mitochondrial carrier SLC25A34 links clock, diet, and temperature control of interorganellar lipid cycling.

bioRxiv : the preprint server for biology·2026
Same author

Cell-type-specific proximity labeling of organ secretomes reveals energy balance-dependent proteomic remodeling.

Cell reports·2026
Same author

SLIT3 fragments orchestrate neurovascular expansion and thermogenesis in brown adipose tissue.

Nature communications·2026
Same author

Myocardial radiomics of non-ischemic cardiomyopathy using cardiovascular magnetic resonance: current perspectives and future directions.

Frontiers in cardiovascular medicine·2026
Same author

Cell type-specific proximity labeling of organ secretomes reveals energy balance-dependent proteomic remodeling.

bioRxiv : the preprint server for biology·2026

Related Experiment Video

Updated: Aug 28, 2025

Author Spotlight: Illuminating New Avenues for Adipose Tissue Metabolism and Disease Prevention
02:55

Author Spotlight: Illuminating New Avenues for Adipose Tissue Metabolism and Disease Prevention

Published on: October 6, 2023

1.5K

Fructose: Not sweet enough for brown fat?

Kaja Plucińska1, Samir Zaman1, Paul Cohen1

  • 1Laboratory of Molecular Metabolism, The Rockefeller University, New York, NY, USA.

Cell Reports. Medicine
|September 21, 2022
PubMed
Summary

High fructose intake lowers glucose absorption in brown adipose tissue (BAT) but does not impact its oxidative function. These metabolic changes occur independently of gut microbiome shifts.

Area of Science:

  • Metabolic research
  • Human physiology
  • Nutritional science

Background:

  • Brown adipose tissue (BAT) plays a crucial role in thermogenesis and glucose metabolism.
  • Dietary fructose is increasingly implicated in metabolic dysfunction.
  • The impact of high fructose consumption on BAT glucose uptake and oxidative capacity requires further elucidation.

Discussion:

  • High fructose consumption significantly reduces glucose uptake in human brown fat.
  • This reduction in glucose uptake occurs without a corresponding decrease in the tissue's oxidative capacity.
  • The observed effects on brown fat metabolism are not mediated by changes in the gut microbiome.

Key Insights:

  • Fructose-induced metabolic alterations in BAT are distinct from general oxidative stress.

More Related Videos

Functional Imaging of Brown Fat in Mice with 18F-FDG micro-PET/CT
10:53

Functional Imaging of Brown Fat in Mice with 18F-FDG micro-PET/CT

Published on: November 23, 2012

19.2K
Cerenkov Luminescence Imaging of Interscapular Brown Adipose Tissue
06:28

Cerenkov Luminescence Imaging of Interscapular Brown Adipose Tissue

Published on: October 7, 2014

13.4K

Related Experiment Videos

Last Updated: Aug 28, 2025

Author Spotlight: Illuminating New Avenues for Adipose Tissue Metabolism and Disease Prevention
02:55

Author Spotlight: Illuminating New Avenues for Adipose Tissue Metabolism and Disease Prevention

Published on: October 6, 2023

1.5K
Functional Imaging of Brown Fat in Mice with 18F-FDG micro-PET/CT
10:53

Functional Imaging of Brown Fat in Mice with 18F-FDG micro-PET/CT

Published on: November 23, 2012

19.2K
Cerenkov Luminescence Imaging of Interscapular Brown Adipose Tissue
06:28

Cerenkov Luminescence Imaging of Interscapular Brown Adipose Tissue

Published on: October 7, 2014

13.4K
  • The gut microbiome does not appear to be a primary mediator of fructose's effects on BAT glucose metabolism.
  • Findings highlight a specific mechanism by which dietary fructose may negatively impact metabolic health.

    • Outlook:

    • Further research into the molecular pathways linking fructose to reduced BAT glucose uptake.
    • Investigating potential therapeutic strategies to counteract fructose-induced metabolic changes in BAT.
    • Exploring the long-term consequences of impaired BAT glucose metabolism on overall energy balance and weight regulation.