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Common human genetic variants of APOE impact murine COVID-19 mortality

Benjamin N Ostendorf1,2,3,4, Mira A Patel5, Jana Bilanovic5

  • 1Laboratory of Systems Cancer Biology, The Rockefeller University, New York, NY, USA. bostendorf@rockefeller.edu.

Nature
|September 21, 2022
PubMed
Summary

Apolipoprotein E (APOE) gene variants influence COVID-19 severity. APOE2 and APOE4 alleles are linked to worse outcomes, increased viral load, and impaired immune response in mice and humans.

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