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The Naturalistic Cannabis Administration Protocol (NCAP): A Proof-of-Concept Study.

Michelle St Pierre¹, Sarah Daniels¹, Tatiana A Sanchez¹

¹Department of Psychology, the University of British Columbia, Kelowna, BC, Canada.

Journal of Psychoactive Drugs

|September 21, 2022

Summary

The Naturalistic Cannabis Administration Protocol (NCAP) allows for ecologically valid cannabis research by enabling participants to self-administer cannabis at home. This novel approach proved safe and feasible for studying acute cannabis effects in real-world settings.

Keywords:

Methodology acute cannabis intoxication cannabis research experimental design

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Area of Science:

Psychology
Neuroscience
Cannabis Research

Background:

Laboratory studies on cannabis effects lack ecological validity due to controlled environments.
Clinical settings can introduce confounding factors like stigma and stereotype threat.
Liberalized cannabis regulations permit more naturalistic research approaches.

Purpose of the Study:

To introduce and validate the Naturalistic Cannabis Administration Protocol (NCAP) for studying acute cannabis effects.
To assess the safety and feasibility of conducting cannabis research in participants' natural environments.
To bridge the gap between controlled lab settings and real-world cannabis use.

Main Methods:

Developed the Naturalistic Cannabis Administration Protocol (NCAP).
Two studies involved participants (N=79) self-administering chosen cannabis at home.
Participants engaged in remote leisure activities or cognitive assessments via videoconference.

Main Results:

The NCAP demonstrated safety and feasibility across two independent studies.
No adverse events were reported by participants using the NCAP.
The protocol successfully facilitated remote assessment of cannabis effects in naturalistic settings.

Conclusions:

The NCAP offers an ecologically valid method for cannabis research.
This protocol can reduce barriers and enhance research capabilities in the evolving landscape of cannabis use.
The NCAP supports more realistic investigations into the acute effects of cannabis.