Bone defect development in experimental canine peri-implantitis models: a systematic review.

Area of Science:

• Dental Implantology
• Periodontology
• Preclinical Research

Background:

• Peri-implantitis, an inflammatory condition, leads to bone loss around dental implants.
• Canine models are frequently used in preclinical research to study peri-implantitis.
• Understanding bone defect progression is crucial for implant success.

Purpose of the Study:

• To systematically review bone defect formation in canine models of ligature-induced peri-implantitis.
• To quantify expected bone loss over time.
• To investigate if implant surface characteristics influence bone loss.

Main Methods:

• Systematic literature search across four major databases.
• Inclusion of 36 studies involving 1082 implants in canine models.
• Analysis using linear regression and linear mixed models to assess bone loss and influencing factors.

Main Results:

• A mean incremental bone defect depth of 0.08 mm per week was observed.
• After 12 weeks, defect depths varied significantly, ranging from 0.7 to 5 mm.
• Implant surface type was not identified as a significant factor in bone defect depth at 12 weeks.

Conclusions:

• Bone loss in ligature-induced peri-implantitis models in dogs is variable.
• Current evidence does not support a clear link between different implant surfaces and the extent of bone loss.