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Rous Sarcoma Virus (RSV) and Cancer01:03

Rous Sarcoma Virus (RSV) and Cancer

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Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand  RNA genome. Its genome consists of four main open...
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Related Experiment Video

Updated: Aug 28, 2025

Establishment of a Primary Culture of Patient-derived Soft Tissue Sarcoma
07:55

Establishment of a Primary Culture of Patient-derived Soft Tissue Sarcoma

Published on: April 11, 2018

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Primary cardiac sarcoma presenting with easy bruising: a case report.

Rina Mishra1, Ealaf Shemmeri2, Saroj Pani3

  • 1Department of Medicine, Albany Medical Center, 43 New Scotland Ave, Albany, NY 12208, USA.

European Heart Journal. Case Reports
|September 22, 2022
PubMed
Summary

This case study highlights a rare primary cardiac sarcoma in the right heart presenting with thrombocytopenia. Early diagnosis and a multidisciplinary approach are crucial for managing this aggressive malignancy.

Keywords:
Case reportPrimary cardiac sarcomaThrombocytopeniaTransthoracic echo

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Area of Science:

  • Cardiovascular Oncology
  • Hematology
  • Diagnostic Imaging

Background:

  • Primary cardiac sarcomas are rare, aggressive malignancies comprising 65% of primary malignant cardiac tumors.
  • These tumors often present with constitutional symptoms like dyspnea, weight loss, and fatigue, with prognosis influenced by tumor location.
  • Thrombocytopenia is a rare but significant presenting symptom.

Observation:

  • An 80-year-old male presented with dyspnea, easy bruising, and chest pain, alongside significant thrombocytopenia.
  • Multimodal imaging, including echocardiography, CT, and cardiac MRI, identified a large right heart mass.
  • Myocardial biopsy confirmed a high-grade angiosarcoma.

Findings:

  • The patient's advanced age and tumor involvement of the interventricular septum precluded surgical resection.
  • Palliative chemotherapy was initiated as the chosen treatment strategy.
  • Differential diagnoses for cardiac masses include various benign and malignant tumors.

Implications:

  • This case underscores the importance of considering rare diagnoses like primary cardiac sarcoma in patients with unexplained thrombocytopenia.
  • Multimodal imaging is essential for accurate diagnosis and staging of cardiac tumors.
  • Individualized, multidisciplinary care is paramount for optimizing outcomes in cardiac sarcoma patients.