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Nanoscale covalent organic frameworks as theranostic platforms for oncotherapy: synthesis, functionalization, and
Qun Guan1, Guang-Bo Wang1, Le-Le Zhou1
1College of Chemistry, Chemical Engineering and Materials Science, Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong, Key Laboratory of Molecular and Nano Probes, Ministry of Education, Shandong Normal University Jinan 250014 P. R. China guangbo.wang@sdnu.edu.cn yubindong@sdnu.edu.cn.
Abstract:
Cancer nanomedicine is one of the most promising domains that has emerged in the continuing search for cancer diagnosis and treatment. The rapid development of nanomaterials and nanotechnology provide a vast array of materials for use in cancer nanomedicine. Among the various nanomaterials, covalent organic frameworks (COFs) are becoming an attractive class of upstarts owing to their high crystallinity, structural regularity, inherent porosity, extensive functionality, design flexibility, and good biocompatibility. In this comprehensive review, recent developments and key achievements of COFs are provided, including their structural design, synthesis methods, nanocrystallization, and functionalization strategies. Subsequently, a systematic overview of the potential oncotherapy applications achieved till date in the fast-growing field of COFs is provided with the aim to inspire further contributions and developments to this nascent but promising field. Finally, development opportunities, critical challenges, and some personal perspectives for COF-based cancer therapeutics are presented.
Insights
Covalent organic frameworks (COFs) show promise for cancer nanomedicine due to their unique properties. This review details COF design, synthesis, and applications in cancer therapy, highlighting future opportunities.
Area of Science:
- Materials Science
- Nanotechnology
- Oncology
Background:
- Cancer nanomedicine utilizes nanomaterials for diagnosis and treatment.
- Covalent organic frameworks (COFs) are emerging as versatile nanomaterials.
- COFs offer high crystallinity, porosity, functionality, and biocompatibility.
Purpose of the Study:
- To provide a comprehensive review of recent developments in COFs for cancer nanomedicine.
- To systematically overview the oncotherapy applications of COFs.
- To present future opportunities and challenges in COF-based cancer therapeutics.
Main Methods:
- Review of recent literature on COF structural design, synthesis, and functionalization.
- Systematic analysis of COF applications in cancer therapy.
- Discussion of development opportunities and challenges.
Main Results:
- COFs possess advantageous properties for cancer nanomedicine.
- Various COFs have demonstrated potential in oncotherapy.
- Key achievements in COF structural design and synthesis are highlighted.
Conclusions:
- COFs represent a promising class of materials for advanced cancer nanomedicine.
- Further research is needed to overcome challenges and realize the full therapeutic potential of COFs.
- COF-based cancer therapeutics offer significant future development opportunities.
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