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Colloidal hydroxyethyl starch for tumor-targeted platinum delivery.

Chen Xiao^1,2, Hang Hu^1,2, Hai Yang^1,2

¹National Engineering Research Center for Nanomedicine, College of Life Science and Technology, Huazhong University of Science and Technology Wuhan 430074 China zifuli@hust.edu.cn +86 27 87792234 +86 27 87792234.

Nanoscale Advances

|September 22, 2022

Summary

Hydroxyethyl starch (HES), a plasma volume expander, was engineered into a novel nanodrug delivery system for cis-platinum chemotherapy. This HES-based system demonstrated enhanced anticancer activity against hepatoma cells, offering a promising platform for clinical translation.

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A Tripeptide-Stabilized Nanoemulsion of Oleic Acid

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Published on: February 27, 2019

Area of Science:

Biomaterials Science
Nanotechnology
Cancer Therapeutics

Background:

Cis-platinum is a first-line chemotherapy drug with limitations including poor solubility, short half-life, and severe side effects.
Existing platinum-based nano drug delivery systems (NDDS) face challenges in clinical application due to safety concerns, complex fabrication, and limited cellular uptake.

Purpose of the Study:

To develop a novel, safe, and effective cis-platinum delivery nanoplatform using hydroxyethyl starch (HES).
To evaluate the physicochemical properties and anticancer efficacy of the HES-based cis-platinum nanodelivery system.

Main Methods:

Characterization of HES nanoparticles using Transmission Electron Microscopy (TEM), Atomic Force Microscopy (AFM), and Dynamic Light Scattering (DLS).
Conjugation of cis-platinum prodrug to HES via ester bonds and decoration with lactobionic acid (LA) for active targeting.
In vitro assessment of antitumor activity against hepatoma carcinoma cells.

Main Results:

HES forms colloidal nanoparticles (15-40 nm) with a hyperbranched, compact structure, suitable as a nanocarrier.
The HES-based cis-platinum nanoplatform exhibited enhanced in vitro antitumor activity compared to free cis-platinum.
Lactobionic acid decoration improved targeting and efficacy.

Conclusions:

Hydroxyethyl starch (HES) is a viable and promising nanocarrier for drug delivery.
The developed HES-based cis-platinum nanodelivery system shows potential for improved cancer treatment.
This study highlights the clinical translation potential of HES for advanced nano drug delivery systems.