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Updated: Aug 28, 2025

Generation of Zerovalent Metal Core Nanoparticles Using n-2-aminoethyl-3-aminosilanetriol
Published on: February 11, 2016
Covalently functionalized uniform amino-silica nanoparticles. Synthesis and validation of amine group accessibility
Peter J Miller1, Daniel F Shantz1
1Department of Chemical and Biomolecular Engineering, Tulane University 6823 St. Charles Avenue New Orleans LA 70118 USA dshantz@tulane.edu.
Abstract:
This paper describes the synthesis and characterization of colloidally stable, 18 nm silica nanoparticles that are functionalized with amine groups. Electron microscopy, small-angle X-ray scattering (SAXS), and dynamic light scattering show the amine grafting does not impact particle size. SAXS and DLS confirm the particles do not aggregate at 10 mg mL-1 and pH 2 for 30 days. Ninhydrin analysis, fluorescamine binding, and NMR studies of carboxylic acid binding show that the amines are present on the surface and accessible with maximum loading calculated to be 0.14 mmol g-1. These materials should find a range of use in nanotechnology applications.
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