Towards a framework for evaluating and reporting Hansen solubility parameters: applications to particle dispersions

Area of Science:

• Materials Science
• Physical Chemistry
• Formulation Science

Background:

• Understanding particulate systems is crucial for knowledge-based formulations.
• Hansen solubility parameters (HSP) are vital for assessing phase compatibility.
• Current HSP determination methods can be subjective and limited by single characterization techniques.

Purpose of the Study:

• To develop a generalized, technology-agnostic procedure for determining particle HSP.
• To address the limitations of existing HSP determination methods.
• To improve the accuracy and reliability of HSP values for particulate systems.

Main Methods:

• Introduced a combinatorics-based procedure for HSP evaluation.
• Utilized analytical centrifugation data to assess dispersion stability.
• Analyzed stability trajectories of SiN particles in various liquids.

Main Results:

• Demonstrated a novel procedure for evaluating particle HSP.
• Successfully deduced particle-liquid compatibility using stability data.
• Showcased the application with SiN particles synthesized in gas phase.

Conclusions:

• The proposed method offers a more robust approach to HSP determination.
• This advancement aids in achieving reliable and informative HSP values.
• Facilitates knowledge-based formulation development through accurate particle-liquid interaction assessment.