Gold-iron oxide nanohybrids: insights into colloidal stability and surface-enhanced Raman detection

Nanoparticles are acquiring an ever increasing role in analytical technologies for enhanced applications such as signalling of hazardous dyes. One challenge for the synthesis of hybrid nanomaterials is to control their shape, size and properties. The colloidal and interfacial properties of initial nanoparticles are decisive for the formation, growth and characteristics of nanohybrids. Our objective is to combine the advantages of iron oxide nanoparticles for magnetic separation with nanoscale gold for a surface enhanced Raman scattering (SERS) effect which could be used e.g. for improved detection of dye molecules. We synthesized iron oxide nanoparticles (∼10 nm) with a high saturation magnetization of around 80 Am² kg^-1 and coupled nanoscale gold to these particles. The focus was set in testing multiple approaches to combine these two materials with the goal of understanding and discussing the effect of the colloidal stability of iron oxide nanoparticles on the properties of the hybrid material. Stability is a seldom addressed issue; however, it plays a critical role for guaranteeing a homogeneous distribution of the gold on the iron oxide surface. We characterized the produced materials with UV/Vis spectroscopy, dynamic light scattering, and transmission electron microscopy, and their capability to enhance Raman signals is investigated. The seed-mediated growth method of oleate and PEG-stabilized magnetic particles yielded the best enhancement of Raman scattering for identification of the dye Rhodamin 6G. This approach can be used to couple gold nanoparticles to other surfaces and microfluidic devices. The presented method might pave the way to further applications in diagnostics or also in environmental approaches and beyond.