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Updated: Aug 28, 2025

Preparation, Purification, and Characterization of Lanthanide Complexes for Use as Contrast Agents for Magnetic Resonance Imaging
Published on: July 21, 2011
Formation of gadolinium-ferritin from clinical magnetic resonance contrast agents
Jitka Neburkova1, Aaron M Rulseh2, Shery L Y Chang3
1Institute of Organic Chemistry and Biochemistry of the CAS Flemingovo nam. 2 166 10 Prague Czechia cigler@uochb.cas.cz.
Abstract:
Gadolinium deposition in the brain following administration of gadolinium-based contrast agents (GBCAs) has led to health concerns. We show that some clinical GBCAs form Gd3+-ferritin nanoparticles at (sub)nanomolar concentrations of Gd3+ under physiological conditions. We describe their structure at atomic resolution and discuss potential relevance for clinical MRI.
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