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Related Experiment Video

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Primary Culture of Human Vestibular Schwannomas

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Published on: July 20, 2014

A Case of Multiple Plexiform Schwannomas.

Somdatta Bhaumik¹, Thanka Johnson¹, Vinutha Gali¹

¹Pathology, Sree Balaji Medical College and Hospital, Chennai, IND.

|September 22, 2022

Summary

Plexiform schwannoma, a nerve sheath tumor, presents as multinodular growths. This case report details a 37-year-old female diagnosed with plexiform schwannoma via histopathology.

Keywords:

hematoxylin and eosin histopathology neurofibromatosis type 2 plexiform schwannoma schwann cell neoplasm

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Area of Science:

Pathology
Oncology
Dermatology

Background:

Schwannoma is a nerve sheath tumor originating from neoplastic Schwann cells.
The plexiform variant exhibits a multinodular growth pattern, distinct from conventional schwannoma.
These tumors are typically slow-growing and can occur along peripheral or cranial nerves.

Observation:

A 37-year-old female presented with multiple swellings on her right forearm, wrist, and hand.
Clinical presentation included skin-colored tumors along nerve distributions.
The tumors ranged from 2 to 4 cm in size.

Findings:

Histopathological examination of biopsy specimens confirmed plexiform schwannoma.
Microscopic analysis revealed biphasic tumor architecture with Antoni A and Antoni B tissues.
Verocay bodies were observed in the compact Antoni A areas.

Implications:

This case highlights the importance of histopathological evaluation for diagnosing plexiform schwannoma.
Understanding the characteristics of plexiform schwannoma aids in clinical management and patient counseling.
Further research into the specific genetic or molecular underpinnings of plexiform schwannoma may offer targeted therapeutic strategies.