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Published on: January 26, 2024
Clinical Effect of Ear Endoscopic Intervention on CMEC Patients and Analysis of the Relationship between ROS, P-Akt,
Ming Yang1, Longqiu Yang2, Lang Wan2
1E.N.T. Department, The First Hospital of Nanchang City, Nanchang 330006, China.
Abstract:
The clinical efficacy of ear endoscopic intervention in patients with congenital middle ear cholesteatoma (CMEC) is explored, and the relationship between the expression of reactive oxygen species (ROS), phosphorylated protein kinase B (P-Akt), hypoxia-inducible factor-1 α (HIF-1α) and the degree of bone damage are analyzed. A total of 72 CMEC patients admitted to the otolaryngology department of our hospital from 2019 to January 2021 for surgical treatment are selected. According to the different intervention methods, the microscope group and the otolaryngology intervention group are established, respectively, with 36 patients in each group. The patients in the microscope group are treated with a microscope for middle ear cholesteatoma surgery, and the patients in the otoscope intervention group are treated with an otoscope for middle ear cholesteatoma surgery. The experimental results show that ear endoscopic intervention has better clinical efficacy for CMEC patients, which can effectively shorten the operation time, reduce the incidence of postoperative complications, and effectively improve the hearing of patients.
Insights
Ear endoscopic intervention shows superior clinical efficacy for congenital middle ear cholesteatoma (CMEC). This method shortens operation time, reduces complications, and improves patient hearing outcomes.
Area of Science:
- Otolaryngology
- Surgical Innovation
- Molecular Biology
Background:
- Congenital middle ear cholesteatoma (CMEC) presents unique surgical challenges.
- Understanding the molecular mechanisms, including reactive oxygen species (ROS), P-Akt, and HIF-1α, may correlate with bone damage in CMEC.
- Optimizing surgical techniques is crucial for improving patient outcomes.
Purpose of the Study:
- To evaluate the clinical efficacy of ear endoscopic intervention versus traditional microscopic surgery for CMEC.
- To analyze the relationship between specific molecular markers (ROS, P-Akt, HIF-1α) and the extent of bone damage in CMEC patients.
Main Methods:
- A comparative study involving 72 CMEC patients undergoing surgical treatment.
- Patients were divided into two groups: microscope intervention (36 patients) and ear endoscopic intervention (36 patients).
- Surgical outcomes, operation time, complication rates, and hearing improvement were assessed.
Main Results:
- Ear endoscopic intervention demonstrated significantly better clinical efficacy compared to the microscope group.
- The endoscopic approach led to a shorter operation time and a reduced incidence of postoperative complications.
- Patients undergoing endoscopic intervention showed effective improvement in hearing.
Conclusions:
- Ear endoscopic intervention is a highly effective treatment for CMEC.
- The technique offers advantages in terms of surgical efficiency and patient recovery.
- Further research may explore the role of ROS, P-Akt, and HIF-1α in CMEC progression and bone erosion.
