Photothermal release of an encapsulated therapeutic agent from polymer-wrapped gold nanoparticles
Daina V Baker1, Khaled M Arafeh1, Amir Asadirad1
14D LABS, Department of Chemistry, Simon Fraser University 8888 University Drive Burnaby BC V5A 1S6 Canada nbranda@sfu.ca.
Abstract:
Visible light is used to generate heat from gold nanoparticles wrapped in an amphiphilic polymer shell and trigger a reverse Diels-Alder reaction of a 'caged' tyrphostin therapeutic agent. The hydrophilic nature of the released agent results in it travelling from the polymer to the bulk medium, while the byproduct of the reaction is trapped in the hydrophobic layer of the nano-assembly.
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