Related Experiment Video
Updated: Aug 28, 2025
11:44
Analysis of Combinatorial miRNA Treatments to Regulate Cell Cycle and Angiogenesis
Published on: March 30, 2019
7.7K
Circular RNA Controls Tumor Occurrence and Development via Cell Cycle Regulation
Fang Liu1, Rongfeng Qu1, Limin Yang1
1Department of Hematology and Oncology, The Second Hospital of Jilin University, Changchun, Jilin, People's Republic of China.
Oncotargets and Therapy
|September 22, 2022
Summary
Circular RNAs (circRNAs) regulate cell cycle and tumor growth via miRNA sponging and protein interactions. Understanding these mechanisms offers insights for novel cancer diagnostics and therapeutics.
Area of Science:
- Molecular Biology
- Oncology
- Genetics
Background:
- Circular RNAs (circRNAs) are key regulators in disease pathogenesis.
- Aberrant circRNA expression in tumors disrupts cell cycle control, promoting proliferation and metastasis.
Purpose of the Study:
- To review circRNA-mediated mechanisms influencing cell cycle dysregulation in cancer.
- To highlight the diagnostic, therapeutic, and prognostic potential of circRNAs in oncology.
Main Methods:
- Literature review of studies on circRNA expression and function in various cancer types.
- Analysis of circRNA roles as miRNA sponges, RNA-binding protein interactors, and regulators of gene expression.
Main Results:
- CircRNAs modulate key regulatory factors and cell cycle networks.
- Specific circRNAs are abnormally expressed in tumor cells, leading to uncontrolled proliferation.
Conclusions:
- CircRNAs offer unique characteristics valuable for cancer diagnosis, treatment, and prognosis.
- Further research into circRNA-regulated cell cycle mechanisms can advance circRNA-based cancer therapies and diagnostics.
Related Concept Videos
03:03mTOR Signaling and Cancer Progression
3.9K
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
The mTOR pathway or the...
3.9K
02:34Inhibition of Cdk Activity
4.9K
The orderly progression of the cell cycle depends on the activation of Cdk protein by binding to its cyclin partner. However, the cell cycle must be restricted when undergoing abnormal changes. Most cancers correlate to the deregulated cell cycle, and since Cdks are a central component of the cell cycle, Cdk inhibitors are extensively studied to develop anticancer agents. For instance, cyclin D associates with several Cdks, such as Cdk 4/6, to form an active complex. The cyclin D-Cdk4/6 complex...
4.9K
01:23Negative Regulator Molecules
35.7K
Positive regulators allow a cell to advance through cell cycle checkpoints. Negative regulators have an equally important role as they terminate a cell’s progression through the cell cycle—or pause it—until the cell meets specific criteria.
35.7K
01:05Cancer-Critical Genes II: Tumor Suppressor Genes
7.9K
Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
7.9K
01:27Molecular Factors Affecting Cell Division
3.2K
Several external and internal factors influence the initiation and inhibition of cell division. For instance, the death of nearby cells or the release of human growth hormone (hGH) promotes cell division. In contrast, lack of hGH or crowding of cells can inhibit cell division.
Several proteins function as internal regulators to ensure each cell cycle stage is completed faithfully before proceeding to the next. Regulator molecules may act directly or influence the activity or production of other...
Several proteins function as internal regulators to ensure each cell cycle stage is completed faithfully before proceeding to the next. Regulator molecules may act directly or influence the activity or production of other...
3.2K
02:39Positive Regulator Molecules
5.6K
Mitotic cell division results in daughter cells that exactly resemble the parent cell. However, errors in the DNA replication or distribution of genetic material may lead to genetic mutations that may be passed down to every new cell formed from the resulting abnormal cell. Propagation of such mutant cells is restricted through checkpoint mechanisms present at different stages of the cell cycle. These checkpoints involve regulator molecules that either promote or demote cell cycle events.
5.6K