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Necrosis01:16

Necrosis

4.7K
Necrosis is considered as an “accidental” or unexpected form of cell death that ends in cell lysis. The first noticeable mention of “necrosis” was in 1859 when Rudolf Virchow used this term to describe advanced tissue breakdown in his compilation titled “Cell Pathology”.
Morphological Manifestations of Necrosis
Necrotic cells show different types of morphological appearance depending on the type of tissue and infection. In coagulative necrosis, cells become...
4.7K
Inflammation01:38

Inflammation

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Overview
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Atherosclerosis I: Introduction01:30

Atherosclerosis I: Introduction

45
Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
45
Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

25
Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
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Myocarditis I: Introduction01:21

Myocarditis I: Introduction

23
Myocarditis is inflammation of the myocardium, which is the muscular layer of the heart.EtiologyMyocarditis has a diverse etiology, including a wide range of infectious and non-infectious causes:Infectious CausesViral: Common viruses include Coxsackie A and B, adenovirus, parvovirus B19, enteroviruses, and influenza A.Bacterial: Examples include infections caused by Streptococcus, Staphylococcus, and Mycoplasma species.Rickettsial: Infections like Rocky Mountain spotted fever can result in...
23
Peripheral Artery Disease I: Introduction01:30

Peripheral Artery Disease I: Introduction

26
Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs, particularly the arteries supplying the thighs and calves. In rare cases, it may involve other arteries, including those in the arms.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty...
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Related Experiment Video

Updated: Aug 28, 2025

A Human Ex Vivo Atherosclerotic Plaque Model to Study Lesion Biology
05:51

A Human Ex Vivo Atherosclerotic Plaque Model to Study Lesion Biology

Published on: May 6, 2014

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Regulated Necrosis in Atherosclerosis.

Pauline Puylaert1, Michelle Zurek1, Katey J Rayner2,3

  • 1Laboratory of Physiopharmacology and Infla-Med Centre of Excellence, University of Antwerp, Belgium (P.P., M.Z., G.R.Y.D.M., W.M.).

Arteriosclerosis, Thrombosis, and Vascular Biology
|September 22, 2022
PubMed
Summary
This summary is machine-generated.

Regulated necrosis pathways, including necroptosis and ferroptosis, are key drivers of unstable atherosclerotic plaques. Targeting these cell death mechanisms offers a promising strategy to stabilize plaques and reduce cardiovascular risk.

Keywords:
atherosclerosisferroptosisnecroptosisnecrosispyroptosis

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Area of Science:

  • Cardiovascular Research
  • Cell Death Mechanisms
  • Atherosclerosis Pathophysiology

Background:

  • Atherosclerosis involves lipid-rich plaque formation, posing a significant health threat due to plaque rupture.
  • Vulnerable plaques are characterized by a large necrotic core, highlighting the role of cell death.

Purpose of the Study:

  • To review various forms of regulated necrosis in atherosclerosis.
  • To explore pharmacological strategies for modulating necrosis to stabilize vulnerable plaques.

Main Methods:

  • Literature review of regulated necrosis pathways (necroptosis, ferroptosis, pyroptosis, secondary necrosis).
  • Discussion of the role of these pathways in atherogenesis and plaque destabilization.

Main Results:

  • Multiple forms of regulated necrosis contribute to the development of unstable atherosclerotic plaques.
  • Pharmacological targeting of necrosis pathways shows potential for plaque stabilization.

Conclusions:

  • Understanding regulated necrosis in atherosclerosis is crucial for developing novel therapeutic strategies.
  • Targeting cell death mechanisms may help mitigate residual cardiovascular risk in patients.