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Myopia Development in Tree Shrew Is Associated with Chronic Inflammatory Reactions
Hsiangyu Ku1, Jamie Jiin-Yi Chen2, Min Hu3
1Department of Ophthalmology and Visual Science, Eye and ENT Hospital, Shanghai Medical College, Fudan University, Shanghai 200031, China.
Current Issues in Molecular Biology
|September 22, 2022
Summary
Chronic retinal inflammation contributes to form-deprivation myopia (FDM) development in tree shrews. This study found increased inflammatory markers and altered extracellular matrix in FDM eyes, suggesting inflammation is key to myopia pathogenesis.
Area of Science:
- Ophthalmology
- Pathology
- Animal Models
Background:
- Form-deprivation myopia (FDM) is a significant visual impairment.
- The role of chronic retinal inflammation in FDM pathogenesis remains unclear.
Purpose of the Study:
- To investigate the involvement of chronic retinal inflammation in the development of form-deprivation myopia (FDM).
- To utilize tree shrews as an animal model for studying FDM and associated inflammatory responses.
Main Methods:
- Tree shrews were subjected to form deprivation for 7 and 14 days.
- Refraction and axial length were measured.
- Real-time PCR and immunohistochemistry assessed proinflammatory cytokines (TNF-α, IL-6, IL-8, MCP-1, NF-κB) and matrix proteins (MMP-2, Collagen I).
Main Results:
- Form deprivation induced significant myopic shifts in refractive error.
- Increased expression of proinflammatory cytokines (TNF-α, IL-6, IL-8, MCP-1, NF-κB) was observed in FDM eyes.
- Elevated matrix metalloproteinase-2 and reduced collagen type I expression were noted in FDM eyes.
Conclusions:
- Chronic retinal inflammation plays a crucial role in the pathogenesis of form-deprivation myopia.
- The findings in tree shrews provide insights into the mechanisms underlying myopia development.
