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Related Concept Videos

Modified-Release Drug Delivery Systems: Rate-Programmed II01:19

Modified-Release Drug Delivery Systems: Rate-Programmed II

Rate-programmed drug delivery systems release drugs in a controlled manner to maintain therapeutic levels. Three main designs include reservoir, matrix, and hybrid systems.Reservoir systems consist of a drug core enclosed within a membrane that controls drug release. In non-swelling reservoir systems, polymers like ethyl cellulose or polymethacrylates are used. These do not hydrate in aqueous media and control release through membrane thickness, porosity, or insolubility. This type includes...
Modified-Release Drug Delivery Systems: Classification01:23

Modified-Release Drug Delivery Systems: Classification

Modified-release drug delivery systems improve drug efficacy and minimize side effects by controlling the rate and location of drug release. These systems fall into three categories: rate-programmed, stimuli-activated, and site-targeted.Rate-programmed systems release drugs at a predetermined rate, maintaining consistent therapeutic levels and reducing fluctuations that could lead to toxicity or subtherapeutic effects. These systems use polymeric matrices, reservoir-based designs, or osmotic...
Modified-Release Drug Delivery Systems: Rate-Programmed I01:22

Modified-Release Drug Delivery Systems: Rate-Programmed I

Rate-programmed drug delivery systems (DDS) are designed to release drugs at specific, controlled rates to maintain consistent therapeutic levels. These systems are categorized based on their release mechanisms, including dissolution-controlled DDS, diffusion-controlled DDS, and combined dissolution-diffusion-controlled DDS.In dissolution-controlled DDS, the release rate depends on the slow dissolution of the drug itself or the surrounding matrix. Drugs with inherently slow dissolution rates,...
Modified-Release Drug Delivery Systems: Stimuli-Activated01:30

Modified-Release Drug Delivery Systems: Stimuli-Activated

Stimuli-activated drug delivery systems are designed to release drugs in response to specific physical, chemical, or biological stimuli. These systems often utilize hydrogels—three-dimensional, hydrophilic polymer networks capable of swelling in aqueous environments and retaining significant fluid volumes. Upon exposure to particular stimuli, these hydrogels undergo structural transitions that allow the embedded drug to be released. Due to this adaptive behavior, such systems are also called...

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Related Experiment Video

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An Injectable and Drug-loaded Supramolecular Hydrogel for Local Catheter Injection into the Pig Heart
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Ultrasound-Induced Drug Release from Stimuli-Responsive Hydrogels.

Tyus J Yeingst1, Julien H Arrizabalaga1, Daniel J Hayes1,2,3

  • 1Department of Biomedical Engineering, The Pennsylvania State University, University Park, Centre County, PA 16802, USA.

Gels (Basel, Switzerland)
|September 22, 2022
PubMed
Summary

Ultrasound-responsive hydrogels offer controlled drug delivery. This review explores their mechanisms, innovative designs, and applications in cancer treatment and tissue engineering.

Keywords:
Tissue engineeringcancer therapycontrolled drug releasedrug deliveryhydrogelspolymerssmart hydrogelsstimuli-responsivethermoresponsive materialsultrasound

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Area of Science:

  • Biomaterials Science
  • Drug Delivery Systems
  • Nanotechnology

Background:

  • Stimuli-responsive hydrogels enable controlled drug release via external triggers.
  • Ultrasound offers non-invasive, deep-penetrating advantages for localized drug delivery.
  • Hydrogel platforms provide spatial and temporal control over therapeutic payloads.

Purpose of the Study:

  • To review the current understanding of ultrasound-responsive hydrogels for drug delivery.
  • To examine mechanisms of ultrasound-induced payload release and hydrogel activation.
  • To highlight innovative hydrogel designs and recent applications in cancer therapy and tissue engineering.

Main Methods:

  • Literature review of ultrasound-responsive hydrogels.
  • Analysis of mechanisms for ultrasound-triggered drug release.
  • Summary of current and emerging applications.

Main Results:

  • Ultrasound provides precise, non-invasive control over drug release from hydrogels.
  • Novel hydrogel formulations and design strategies enhance ultrasound responsiveness.
  • Applications in cancer treatment and tissue engineering demonstrate significant potential.

Conclusions:

  • Ultrasound-responsive hydrogels represent a promising frontier in targeted drug delivery.
  • Further research into advanced hydrogel designs will expand therapeutic possibilities.
  • These systems offer significant future potential for advanced medical treatments.