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Related Experiment Video

Updated: Aug 28, 2025

The Attentional Set Shifting Task: A Measure of Cognitive Flexibility in Mice
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Selection of Mice for Object Permanence Cognitive Task Solution.

Olga Viktorovna Perepelkina1, Inga Igorevna Poletaeva1

  • 1Biology Department, Moscow State University, Vorobieby Gori, 1, Build. 12, 119234 Moscow, Russia.

Neurology International
|September 22, 2022
PubMed
Summary

Mice selectively bred for puzzle-box success demonstrated improved cognitive abilities, specifically in solving tasks requiring object permanence. This selection process enhanced their problem-solving skills in navigating blocked underpasses.

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Area of Science:

  • Behavioral Neuroscience
  • Animal Cognition

Background:

  • The puzzle-box test assesses cognitive abilities, including object permanence, in rodents.
  • Selective breeding can alter behavioral traits and cognitive functions in animal models.

Purpose of the Study:

  • To investigate the effects of selective breeding on cognitive abilities related to problem-solving in mice.
  • To determine if selection for success in a puzzle-box task influences the object permanence rule in mice.

Main Methods:

  • Selective breeding of mice over five generations for high ('plus') and low ('minus') scores in a puzzle-box test.
  • Assessing the ability to solve a blocked underpass task, indicative of object permanence.
  • Evaluating neophobic responses using a hyponeophagia test.
Keywords:
cognitive taskgenetic differencesnoveltyobject permanencepuzzle-boxselection

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Related Experiment Videos

Last Updated: Aug 28, 2025

The Attentional Set Shifting Task: A Measure of Cognitive Flexibility in Mice
09:15

The Attentional Set Shifting Task: A Measure of Cognitive Flexibility in Mice

Published on: February 4, 2015

27.6K
Novel Object Recognition Test for the Investigation of Learning and Memory in Mice
08:52

Novel Object Recognition Test for the Investigation of Learning and Memory in Mice

Published on: August 30, 2017

74.1K
Novel Object Recognition and Object Location Behavioral Testing in Mice on a Budget
05:57

Novel Object Recognition and Object Location Behavioral Testing in Mice on a Budget

Published on: November 20, 2018

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Main Results:

  • The '+' strain mice showed a significantly higher success rate in solving the blocked underpass task compared to the '-' strain and control populations.
  • While both strains manipulated the plug, '+' mice were more effective in opening the underpass.
  • The '+' strain mice exhibited increased consumption of novel food, suggesting altered neophobia.

Conclusions:

  • Selective breeding for puzzle-box task success effectively enhanced problem-solving abilities linked to object permanence in mice.
  • The selection process influenced the mice's capacity to overcome physical obstacles to reach a goal.
  • Cognitive performance in the puzzle-box test is heritable and can be modified through targeted selective breeding.