Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Circumferential tracheal replacement with costal cartilage.

F Eckersberger, E Moritz, E Wolner

    The Journal of Thoracic and Cardiovascular Surgery
    |August 1, 1987
    PubMed
    Summary

    This study demonstrates a novel technique for tracheal replacement using autogenous cartilage in dogs, successfully restoring ciliated epithelium and mucociliary clearance without permanent foreign materials.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    RHD alleles in Brazilian blood donors with weak D or D-negative phenotypes.

    Transfusion medicine (Oxford, England)·2012
    Same author

    Human neutrophil alloantigen-1a, -1b, -2, -3a and -4a frequencies in Brazilians.

    Tissue antigens·2009
    Same author

    Molecular studies reveal that A134T, G156A and G1333A SNPs in the CD177 gene are associated with atypical expression of human neutrophil antigen-2.

    Vox sanguinis·2009
    Same author

    The efficacy of inhibitors involved in spermidine metabolism in Plasmodium falciparum, Anopheles stephensi and Trypanosoma evansi.

    Parasitology research·2004
    Same author

    Increased cystatin C in astrocytes of transgenic mice expressing the K670N-M671L mutation of the amyloid precursor protein and deposition in brain amyloid plaques.

    Neurobiology of disease·2001
    Same author

    Successful removal of different metal stents from the hepatobiliary system.

    Endoscopy·2001

    Area of Science:

    • Regenerative Medicine
    • Biomaterials Science
    • Surgical Innovation

    Background:

    • Permanent foreign materials in tracheal replacement cause granulation tissue, leading to stenosis and preventing functional ciliated epithelium.
    • Existing methods for tracheal repair face challenges in long-term integration and functional recovery.

    Purpose of the Study:

    • To evaluate a novel technique for circumferential tracheal replacement using autogenous cartilage and a temporary silicone prosthesis.
    • To assess the regeneration of functional ciliated epithelium and mucociliary clearance in the neotracheal segment.

    Main Methods:

    • Circumferential replacement of a 5 cm segment of thoracic trachea in dogs using autogenous cartilage-perichondrium strips.
    • Use of a temporary silicone rubber tracheal prosthesis with absorbable polyglactin 910 sewing rings.
    • Endoscopic removal of the prosthesis after 6 months and subsequent histological and functional analysis.

    Main Results:

    • The neotracheal wall stabilized within 6 months, allowing for prosthesis removal.
    • Complete coverage with ciliated epithelium was observed within 4 weeks post-explant.
    • Demonstrated functional mucociliary clearance with transport speeds of 18-21 mm/min.
    • Transmission electron microscopy confirmed normal cilia structure and arrangement.

    Conclusions:

    • Autogenous cartilage transplantation combined with a temporary prosthesis is a viable strategy for tracheal replacement.
    • This technique successfully promotes regeneration of functional ciliated epithelium and restores mucociliary clearance.
    • Avoiding permanent foreign material incorporation is key to successful long-term tracheal reconstruction.

    Related Experiment Videos