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Investigation of optimum hemoglobin levels in older patients with chronic kidney disease

Osman Kara1, Pinar Soysal2, Muharrem Kiskac3

  • 1Department of Hematology, Atasehir Medicana International Health Group, Istanbul, Turkey.

Aging Clinical and Experimental Research
|September 22, 2022
PubMed

Insights

Target hemoglobin levels for older adults with chronic kidney disease (CKD) are identified. Maintaining hemoglobin between 11.8-12.1 g/dL for females and 12.6-12.8 g/dL for males can prevent anemia-related complications.

Area of Science:

  • Geriatric Medicine
  • Nephrology
  • Hematology

Background:

  • Anemia is common in older adults with chronic kidney disease (CKD).
  • Anemia is linked to adverse outcomes like muscle weakness, falls, and reduced daily function in the elderly.
  • Optimal hemoglobin (Hgb) targets for this population are not well-defined.

Purpose of the Study:

  • To determine target hemoglobin (Hgb) values in older adults with CKD.
  • To correlate Hgb levels with geriatric assessment parameters including mood, gait, balance, muscle strength, and daily activities.
  • To establish Hgb targets that optimize geriatric assessment outcomes.

Main Methods:

  • A comprehensive geriatric assessment (CGA) was performed on elderly CKD patients.
  • Evaluated parameters included functional status (ADL/IADL), fall risk (Tinetti, TUG), and muscle strength (hand grip).
  • Receiver Operating Characteristic (ROC) analysis identified optimal Hgb levels associated with best CGA performance.

Main Results:

  • 622 elderly CKD patients were studied; 69.3% were female, and 55.7% had anemia.
  • Anemia was associated with dynapenia, high fall risk, and decreased functional capacity in both genders.
  • Optimal Hgb levels were 11.8-12.1 g/dL for females and 12.6-12.8 g/dL for males.

Conclusions:

  • Anemia in older CKD patients is linked to muscle weakness, increased fall risk, and functional decline.
  • Recommended Hgb target ranges are 11.8-12.1 g/dL for older females with CKD.
  • Recommended Hgb target ranges are 12.6-12.8 g/dL for older males with CKD.
Abstract

Keywords:
AnemiaChronic kidney diseaseElderlyHemoglobin

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