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Updated: Aug 28, 2025

Viral Tracing of Genetically Defined Neural Circuitry

Viral Tracing of Genetically Defined Neural Circuitry

Published on: October 17, 2012

Viral Tools for Neural Circuit Tracing.

Qing Liu^1,2, Yang Wu^3,2, Huadong Wang^1,2

¹The Brain Cognition and Brain Disease Institute (BCBDI), Shenzhen Key Laboratory of Viral Vectors for Biomedicine, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions, NMPA Key Laboratory for Research and Evaluation of Viral Vector Technology in Cell and Gene Therapy Medicinal Products, Shenzhen Key Laboratory of Quality Control Technology for Virus-Based Therapeutics, Guangdong Provincial Medical Products Administration, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, China.

Neuroscience Bulletin

|September 22, 2022

Summary

This summary is machine-generated.

Understanding brain function requires dissecting neural circuits. This review highlights advancements in viral tools for cell type-specific neural circuit tracing across species, crucial for neuroscience research.

Keywords:

Anterograde Neural circuit Retrograde Trans-synaptic Viral tool

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Last Updated: Aug 28, 2025

Viral Tracing of Genetically Defined Neural Circuitry

Viral Tracing of Genetically Defined Neural Circuitry

Published on: October 17, 2012

Revealing Neural Circuit Topography in Multi-Color

Revealing Neural Circuit Topography in Multi-Color

Published on: November 14, 2011

Transsynaptic Tracing from Peripheral Targets with Pseudorabies Virus Followed by Cholera Toxin and Biotinylated Dextran Amines Double Labeling

Transsynaptic Tracing from Peripheral Targets with Pseudorabies Virus Followed by Cholera Toxin and Biotinylated Dextran Amines Double Labeling

Published on: September 14, 2015

Area of Science:

Neuroscience
Molecular Biology
Genetics

Background:

Neural circuits form the anatomical basis of brain function.
Dissecting neural circuit structure is key to understanding brain mechanisms.
Viral tracers offer advantages for cell type-specific and circuit-selective tracing.

Purpose of the Study:

To review recent developments in viral tools for neural circuit tracing.
To discuss fundamental principles of using viral tools in neuroscience.
To highlight innovations in optimizing viral tracing tools for diverse species.

Main Methods:

Review of current literature on recombinant neurotropic viruses for neural circuit tracing.
Analysis of viral tool advantages including anterograde, retrograde, and trans-synaptic capabilities.
Examination of innovations in viral tool development and optimization.

Main Results:

Recombinant viruses enable cell type-specific and circuit-selective tracing.
Viral tools facilitate anterograde, retrograde, and trans-synaptic tracing.
Recent innovations enhance the utility of viral tracing across various animal models.

Conclusions:

Viral tools are indispensable for detailed neural circuit analysis.
Advancements in viral technology continue to expand neuroscience research capabilities.
Optimized viral tracing methods are essential for studying complex neural networks in diverse species, including nonhuman primates.