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Related Experiment Videos

A new look at pericardial substitutes.

W H Heydorn, J S Daniel, C E Wade

    The Journal of Thoracic and Cardiovascular Surgery
    |August 1, 1987
    PubMed
    Summary

    New pericardial patches were tested in dogs to prevent adhesions during cardiac surgery reoperations. Most patches showed minimal adhesions, with polytetrafluoroethylene being a good option if calcification is a concern.

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    Area of Science:

    • Biomaterials Science
    • Cardiovascular Surgery
    • Veterinary Pathology

    Background:

    • Pericardial adhesions increase risks during cardiac reoperation.
    • Pericardial substitutes aim to reduce or prevent these adhesions.

    Purpose of the Study:

    • To evaluate the efficacy of five novel pericardial substitutes in preventing adhesions in a canine model.
    • To assess the histological and gross pathological effects of these patches over time.

    Main Methods:

    • Five types of pericardial patches (polytetrafluoroethylene, two glutaraldehyde-stabilized bovine pericardium, formaldehyde-preserved bovine pericardium, glutaraldehyde-stabilized equine pericardium) were implanted in 30 dogs.
    • Dogs were euthanized at 3, 9, and 18 months post-implantation for autopsy and histological examination.
    • Adhesions and epicardial reactions were graded (none, minimal, moderate, severe).

    Main Results:

    • None of the tested materials caused severe pericardial adhesions; nine dogs had no adhesions.
    • Eleven dogs exhibited no epicardial reaction, and only one showed a severe reaction.
    • Adhesions to suture lines occurred in 11 dogs, requiring sharp dissection. Patch type did not significantly influence outcomes.

    Conclusions:

    • The tested pericardial substitutes generally performed well in preventing severe adhesions.
    • Polytetrafluoroethylene may be preferable when concerns about heterologous tissue calcification exist.
    • Patch type did not significantly impact the observed patch behavior or adhesion formation.

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