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Related Concept Videos

Peritoneal Dialysis I: Introduction and Procedure01:30

Peritoneal Dialysis I: Introduction and Procedure

145
Peritoneal dialysis (PD) is a procedure that facilitates the exchange of solutes, waste products, electrolytes, and excess fluid between the blood in the peritoneal capillaries and a dialysis solution introduced into the peritoneal cavity.Principles of Peritoneal Dialysis (PD)Diffusion: Waste products such as urea and electrolytes move from high concentrations in the blood to low concentrations in the dialysate across the peritoneal membrane. This mechanism is driven by the concentration...
145
Peritoneal Dialysis II: Peritoneal Dialysis Systems and Complications01:25

Peritoneal Dialysis II: Peritoneal Dialysis Systems and Complications

90
Peritoneal dialysis (PD) is a medical process that removes waste products and excess fluid from the body using the peritoneal membrane as a natural filter.Peritoneal Dialysis MethodsSeveral methods can be used for peritoneal dialysis, including Acute Intermittent Peritoneal Dialysis, Continuous Ambulatory Peritoneal Dialysis, and Automated Peritoneal Dialysis, also known as Continuous Cyclic Peritoneal Dialysis.Acute Intermittent Peritoneal Dialysis (AIPD) is used for patients with uremic...
90
Peritoneal Dialysis III: Nursing Management01:25

Peritoneal Dialysis III: Nursing Management

118
Peritoneal dialysis, or PD, utilizes the peritoneal membrane as a filter to eliminate excess fluid and waste products. Effective nursing management is essential for ensuring patient safety, preventing complications, and promoting optimal function of the peritoneal dialysis process.Assessment and MonitoringNurses must thoroughly assess the patient before, during, and after each dialysis session. Regular monitoring includes vital signs, daily weight, fluid intake and output, and laboratory values...
118

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Related Experiment Video

Updated: Aug 28, 2025

Surgical Techniques for Catheter Placement and 5/6 Nephrectomy in Murine Models of Peritoneal Dialysis
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A Uremic Pig Model for Peritoneal Dialysis.

Joost C de Vries1, Maaike K van Gelder1, Anneke S Monninkhof1

  • 1Department of Nephrology and Hypertension, University Medical Centre Utrecht, 3508 GA Utrecht, The Netherlands.

Toxins
|September 22, 2022
PubMed
Summary

Researchers developed a porcine model for peritoneal dialysis (PD) research. This model allows for temporary uremia aggravation, simulating dialysis patient conditions for evaluating PD innovations.

Keywords:
animal modelkidney failuremass transfer area coefficientperitoneal dialysisstandard peritoneal permeability assessment

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Area of Science:

  • Nephrology
  • Translational Medicine
  • Animal Models

Background:

  • Growing interest in home dialysis necessitates reliable preclinical models.
  • Evaluating new peritoneal dialysis (PD) technologies requires a suitable large animal model.

Purpose of the Study:

  • To develop and validate a porcine model of chronic kidney injury with inducible uremia for PD research.
  • To assess peritoneal transport characteristics in this novel animal model.

Main Methods:

  • Chronic kidney injury induced via bilateral subtotal renal artery embolization in pigs.
  • Acute-on-chronic kidney injury simulated with gentamicin to achieve uremic levels comparable to dialysis patients.
  • Peritoneal dialysis (PD) applied and peritoneal transport assessed using standard peritoneal permeability assessment (SPA).

Main Results:

  • The model demonstrated stable chronic kidney injury with inducible uremia.
  • PD was successfully implemented, though peritonitis was a common complication.
  • SPA revealed a low peritoneal transport status (D/P creatinine at 4h: 0.41) and specific mass transfer coefficients for urea, creatinine, and phosphate.

Conclusions:

  • The developed porcine model with on-demand uremia aggravation is suitable for PD research.
  • The model exhibits a low peritoneal transport status, providing a specific physiological context for PD innovation testing.