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Protocol for systematic review and network meta-analysis of comparative effectiveness of surgical interventions for

Yun Jeong Lee1,2, Donghwee Kang3, Joo Eon Lee4

  • 1Department of Ophthalmology, Seoul National University Hospital, Seoul, Korea.

BMJ Open
|September 22, 2022
PubMed

Insights

This network meta-analysis compares surgical interventions for primary congenital glaucoma (PCG) in children. It aims to systematically evaluate the efficacy of different surgical treatments for lowering intraocular pressure (IOP) and preventing blindness.

Area of Science:

  • Ophthalmology
  • Pediatric Surgery
  • Evidence-Based Medicine

Background:

  • Primary congenital glaucoma (PCG) is a severe childhood eye condition requiring surgical intervention to prevent vision loss.
  • Current surgical treatments for PCG lack comprehensive comparative effectiveness data.
  • Limited evidence exists on the comparative efficacy of various surgical interventions for PCG.

Purpose of the Study:

  • To systematically compare the efficacy of different surgical interventions for primary congenital glaucoma (PCG).
  • To evaluate the intraocular pressure (IOP)-lowering effects of surgical treatments in pediatric patients.
  • To provide evidence for optimal surgical management of PCG.

Main Methods:

  • Network meta-analysis of randomized controlled trials (RCTs) regardless of language or publication date.
  • Systematic search of Cochrane Central Register of Controlled Trials, Embase, and MEDLINE databases.
  • Assessment of study validity using risk-of-bias tools and evidence quality via the Confidence in Network Meta-Analysis approach.

Main Results:

  • The primary outcome measure is the IOP-lowering effect of surgical interventions.
  • Network diagrams and forest plots will visualize comparative intervention effects.
  • Pairwise effect sizes will be calculated based on available network evidence.

Conclusions:

  • This study will synthesize available evidence on surgical interventions for PCG.
  • Findings will inform clinical decision-making for PCG management.
  • The results will be disseminated through peer-reviewed publication.
Abstract

Keywords:
GlaucomaPaediatric ophthalmology

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