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Perinatal risk factors for infantile hypertrophic pyloric stenosis: A systematic review and meta-analysis

Yazan Y Obaid1, Ahmad A Toubasi1, Farah H Albustanji1

  • 1Faculty of Medicine, University of Jordan, Amman, Jordan, 11962.

Journal of Pediatric Surgery
|September 22, 2022
PubMed

Insights

Infantile hypertrophic pyloric stenosis (IHPS) is linked to male sex, maternal smoking, and bottle-feeding. Further prospective studies are needed to confirm these perinatal risk factors for IHPS.

Area of Science:

  • Pediatric Surgery
  • Neonatal Research
  • Epidemiology

Background:

  • Infantile hypertrophic pyloric stenosis (IHPS) is a common pediatric surgical condition.
  • While diagnosis and treatment are established, perinatal risk factors require further investigation.

Approach:

  • Systematic review and meta-analysis of case-control and cohort studies.
  • Searched Cochrane, Google Scholar, PubMed, and Scopus databases.
  • Assessed study quality using the Newcastle-Ottawa Scale (NOS).

Key Points:

  • Significant associations found between IHPS and male sex, maternal smoking, bottle-feeding, firstborn status, African ethnicity, and cesarean section.
  • No significant associations identified with multiple gestations, preterm labor, summer birth, or small for gestational age (SGA).

Conclusions:

  • Male sex, bottle feeding, maternal smoking, and African ethnicity are significantly associated with IHPS risk.
  • Most included studies were retrospective, highlighting the need for future prospective research to validate these findings.
Abstract

Keywords:
HumanMeta-analysisPyloric stenosisRisk factors

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