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Ecological and evolutionary dynamics of multi-strain RNA viruses
Dennis N Makau1, Samantha Lycett2, Matthew Michalska-Smith3
1Department of Veterinary Population Medicine, University of Minnesota, St. Paul, MN, USA.
Nature Ecology & Evolution
|September 22, 2022
Summary
Interactions between co-circulating virus strains impact transmission dynamics. This review explores multi-strain virus dynamics, ecological and evolutionary factors, and research methods.
Area of Science:
- Virology
- Epidemiology
- Evolutionary Biology
Background:
- Interactions among co-circulating viral strains are often overlooked in transmission studies.
- These interactions can significantly influence host immune responses and viral fitness.
- Understanding these dynamics is crucial for predicting disease spread.
Purpose of the Study:
- To review the ecological and evolutionary perspectives of multi-strain virus dynamics.
- To outline the scales at which these dynamics occur.
- To summarize methods for quantifying strain interactions and discuss host-pathogen influences.
Main Methods:
- Literature review of ecological and evolutionary dynamics.
- Description of immunological, phylogenetic, and mathematical modeling approaches.
- Synthesis of host-pathogen interaction studies.
Main Results:
- Multi-strain dynamics are shaped by ecological and evolutionary factors.
- Various scales exist for multi-strain interactions.
- Immunological, phylogenetic, and modeling approaches quantify these interactions.
- Host-pathogen interactions are key to pathogen co-circulation.
Conclusions:
- Further research is needed to address knowledge gaps in multi-strain virus dynamics.
- Integrating ecological, evolutionary, and immunological perspectives is essential.
- Advanced modeling is crucial for understanding complex viral interactions.
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