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CD3Ɛ immune restorative ability induced by Maitake Pro4x in immunosupressed BALBc mice
Diego Maximo Aguilera-Braico1, Gabriela A Balogh2
1BIOMED-UCA, Laboratory of Biomedical Sciences, Pontifical Catholic Argentine University-UCA, 1600 Alicia Moreau de Justo Avenue, 1007, Buenos Aires, Argentina.
Objectives:
The aim of this research was to determine if the rich beta glucan compound called Maitake Pro4X can recover the T cell/NK population depleted by Dexamethasone treatment in lymph nodes from cancer-free BALBc female mice. A CD3Ɛ molecular FITC labelled marker was used to measure the effect of Maitake D-Fraction Pro4X (5 mg/kg) on T cell/NK cells populations employing flow cytometry from immunosuppressed female BALBc mice in lymph nodes. There were employed other molecular markers such as CD19, CD105, Ly6G.
Results:
Maitake Pro4X (5 mg/kg) was able to recover 42.97% of the depleted CD3Ɛ FITC cell population level in Lymph nodes from immunosuppressed female BALBc mice from 4.328 ± 6.229 to 22.646 ± 12.393 (p < 0.01) using Flow Cytometry. Maitake was also able to significantly increase the Ly6G PE cell population with p < 0.05 in lymph nodes.
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