Intermittent Theta-Burst Stimulation Increases the Working Memory Capacity of Methamphetamine Addicts

Area of Science:

• Neuroscience
• Psychiatry
• Cognitive Science

Background:

• Methamphetamine use disorder (MUD) is associated with significant cognitive deficits, particularly in visual working memory.
• Non-invasive brain stimulation techniques are being explored as potential interventions for cognitive impairment in addiction.

Purpose of the Study:

• To investigate the efficacy of intermittent theta-burst stimulation (iTBS) targeting the left dorsolateral prefrontal cortex (DLPFC) in improving visual working memory in individuals with MUD.
• To compare the effects of active iTBS with a sham control condition.

Main Methods:

• A randomized controlled trial design was employed with five sessions of iTBS delivered to the left DLPFC or vertex (sham control) over five consecutive days.
• Visual working memory was assessed using orientation free-recall tasks administered before stimulation, after the first session, and after the fifth session.

Main Results:

• A single session of iTBS over the left DLPFC significantly enhanced visual working memory performance compared to the sham group.
• iTBS over the left DLPFC led to an increased working memory capacity, with effects potentiated by multiple stimulation sessions.

Conclusions:

• iTBS applied to the left DLPFC represents a promising non-invasive neuromodulation strategy for ameliorating visual working memory deficits in individuals with MUD.
• These findings suggest a potential therapeutic avenue for enhancing cognitive function in addiction recovery.