Alzheimer's Disease and Inflammaging

Area of Science:

• Neuroscience
• Immunology
• Gerontology

Background:

• Alzheimer's disease (AD) is a leading age-related neurodegenerative disorder.
• The amyloid-β cascade hypothesis is the primary theory for AD progression.
• Mechanisms of amyloid-β and tau protein aggregation in neurons are not fully understood.

Purpose of the Study:

• To review the role of inflammaging in neurodegeneration.
• To explore how chronic inflammation contributes to Alzheimer's disease.
• To discuss the link between aging, inflammation, and neurodegenerative diseases.

Main Methods:

• Literature review of studies on aging, inflammation, and neurodegeneration.
• Analysis of the impact of inflammaging on amyloid-β and tau pathology.
• Examination of comorbidities associated with increased inflammation and AD risk.

Main Results:

• Inflammaging, characterized by chronic low-grade inflammation during aging, is implicated in AD pathogenesis.
• Activated proinflammatory cell phenotypes during aging may drive neurodegeneration.
• Inflammation is a shared mechanism in age-related diseases including atherosclerosis, metabolic syndrome, type 2 diabetes mellitus, and AD.

Conclusions:

• Inflammaging is a significant factor in the development of senile plaques and tau fibrils in Alzheimer's disease.
• Inflammatory processes activated during aging and by comorbidities contribute to neurodegeneration.
• Targeting inflammation may offer therapeutic strategies for Alzheimer's disease and related conditions.