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Research Progress on Nanoparticles-Based CRISPR/Cas9 System for Targeted Therapy of Tumors

Dengyun Nie1, Ting Guo1, Miao Yue1

  • 1Taizhou People's Hospital Affiliated to Nanjing University of Chinese Medicine, Taizhou 225300, China.

Biomolecules
|September 23, 2022
PubMed

Insights

Nanoparticles offer a promising solution for delivering CRISPR/Cas9 gene editing technology in cancer therapeutics. This approach aims to overcome current limitations in efficiency and safety for clinical applications.

Area of Science:

  • Biotechnology
  • Genetics
  • Oncology

Background:

  • Cancer is a significant global health threat driven by genetic mutations.
  • CRISPR/Cas9 technology offers powerful gene editing capabilities with potential in oncology.
  • Current limitations in CRISPR/Cas9 efficiency and in vivo safety hinder its clinical application.

Purpose of the Study:

  • To review the latest research on nanoparticle-based CRISPR/Cas9 systems for cancer therapeutics.
  • To explore the potential of nanomedicine in overcoming delivery challenges for CRISPR/Cas9.
  • To provide insights for designing nanocarriers for clinical cancer gene editing.

Main Methods:

  • Literature review of recent studies on nanoparticle-mediated CRISPR/Cas9 delivery.
  • Analysis of research focusing on CRISPR/Cas9 applications in cancer treatment.
  • Examination of nanomedicine advancements relevant to gene editing delivery systems.

Main Results:

  • Nanoparticles show potential as effective delivery vehicles for CRISPR/Cas9 systems.
  • Various nanoparticle platforms are being investigated for targeted cancer gene editing.
  • Advances in nanomedicine are addressing safety and efficiency concerns for in vivo applications.

Conclusions:

  • Nanoparticle-based delivery is a critical strategy for advancing CRISPR/Cas9 cancer therapeutics.
  • Further research and nanocarrier design are essential for successful clinical translation.
  • This review highlights the potential of nanomedicine to enable CRISPR/Cas9 in clinical oncology.
Keywords:
CRISPR/Cas9cancerdeliverynanoparticlestherapy

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