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Published on: December 5, 2020
Antibacterial and Antifungal Sesquiterpenoids: Chemistry, Resource, and Activity
Hang-Ying Li1,2,3, Wen-Qian Yang1, Xin-Zhu Zhou1
1College of Pharmacy, Ningxia Medical University, Yinchuan 750004, China.
Abstract:
Infectious diseases caused by bacteria and fungi are threatening human health all over the world. It is an increasingly serious problem that the efficacies of some antibacterial and antifungal agents have been weakened by the drug resistance of some bacteria and fungi, which makes a great need for new antibiotics. Sesquiterpenoids, with abundant structural skeleton types and a wide range of bioactivities, are considered as good candidates to be antibacterial and antifungal agents. In the past decades, many sesquiterpenoids were isolated from plants and fungi that exhibited good antibacterial and antifungal activities. In this review, the names, source, structures, antibacterial and antifungal degrees, and mechanisms of sesquiterpenoids with antibacterial and antifungal activity from 2012 to 2022 are summarized, and the structure-activity relationship of these sesquiterpenoids against bacteria and fungi is also discussed.
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