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In Vitro Scratch Assay to Demonstrate Effects of Arsenic on Skin Cell Migration
Published on: February 23, 2019
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Epigenetic Dysregulations in Arsenic-Induced Carcinogenesis
Ranakul Islam1, Lei Zhao1, Yifang Wang1
1Department of Medical Oncology, Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA.
Cancers
|September 23, 2022
Summary
Arsenic exposure can lead to cancer and blood vessel formation (angiogenesis) by altering gene expression through epigenetic modifications. This review explores how arsenic disrupts cellular processes, impacting human health.
Area of Science:
- Environmental Science
- Toxicology
- Molecular Biology
Background:
- Arsenic is a toxic metalloid impacting global health, linked to various diseases including cancers.
- Arsenic exposure affects millions worldwide, necessitating research into its health impacts.
- The precise mechanisms by which arsenic induces disease, particularly through gene expression changes, are not fully understood.
Purpose of the Study:
- To review current findings on arsenic-induced epigenetic modifications.
- To explore the role of epigenetics in arsenic-related carcinogenesis and angiogenesis.
- To highlight potential mechanisms of arsenic-induced epigenetic reprogramming and its cellular consequences.
Main Methods:
- Literature review of current discoveries.
- Summary of research on arsenic-induced epigenetic modifications.
- Analysis of proposed mechanisms linking arsenic exposure to cellular dysfunction.
Main Results:
- Arsenic exposure is associated with epigenetic modifications.
- These modifications play a role in cancer development (carcinogenesis) and the formation of new blood vessels (angiogenesis).
- Arsenic can reprogram epigenetic components, altering cell signaling and leading to cellular dysfunction.
Conclusions:
- Epigenetic dysregulation is a key mechanism in arsenic-induced diseases.
- Understanding these epigenetic changes is crucial for addressing arsenic toxicity.
- Further research is needed to fully elucidate the complex interplay between arsenic, epigenetics, and disease pathogenesis.
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