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Updated: Aug 28, 2025

Intracellular Phosphoflow Cytometry of Acute Myeloid Leukemia Patient-Derived Xenotransplants
Published on: June 6, 2025
How I Treat TP53-Mutated Acute Myeloid Leukemia and Myelodysplastic Syndromes
Michael Loschi1,2, Pierre Fenaux3, Thomas Cluzeau1,2
1Hematology Department, University Hospital of Nice, Cote d'Azur University, 06202 Nice, France.
Abstract:
TP53-mutated acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS) are among the myeloid malignancies with the poorest prognosis. In this review, we analyze the prognosis of these two diseases, focussing particularly on the extent of the mono or biallelic mutation status of TP53 mutation, which is largely correlated with cytogenetic complexity. We discuss the possible/potential improvement in outcome based on recent results obtained with new drugs (especially eprenetapopt and magrolimab). We also focus on the impact of allogeneic hematopoietic stem cell transplantation (aHSCT) including post aHSCT treatment.
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