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Lecithin-Polysaccharide Self-Assembled Microspheres for Resveratrol Delivery
Lei Wang1, Congting Lai1, Dong Li1
1Key Laboratory of Agro-Products Postharvest Handling, Ministry of Agriculture and Rural Affairs, College of Biosystems Engineering and Food Science, Zhejiang University, Hangzhou 310058, China.
Antioxidants (Basel, Switzerland)
|September 23, 2022
Summary
Resveratrol
Area of Science:
- Food Science
- Biotechnology
- Materials Science
Background:
- Resveratrol exhibits poor water solubility and low chemical stability, hindering its bioavailability.
- Effective delivery systems are crucial for enhancing resveratrol's therapeutic potential.
Purpose of the Study:
- To develop lecithin-polysaccharide self-assembled microspheres (LPSM) for improved resveratrol delivery.
- To evaluate the stability, antioxidant capacity, and bioavailability of resveratrol encapsulated in LPSM.
Main Methods:
- Synthesized LPSM with a lecithin core and alginate-carboxymethyl chitosan shell.
- Characterized LPSM particle size, zeta potential, and encapsulation efficiency.
- Assessed resveratrol's antioxidant capacity, UV resistance, and release profile in simulated gastric and intestinal environments.
- Evaluated enhanced bioavailability through in vitro simulated digestion.
Main Results:
- Lecithin-polysaccharide self-assembled microspheres (LPSM) achieved high resveratrol encapsulation efficiency (92.78%).
- LPSM enhanced resveratrol's antioxidant capacity and UV resistance.
- LPSM demonstrated controlled release, inhibiting gastric release and promoting sustained intestinal release, leading to increased bioavailability.
Conclusions:
- Lecithin-polysaccharide self-assembled microspheres are a promising carrier for resveratrol.
- LPSM significantly improves resveratrol's stability and bioaccessibility for enhanced delivery.
