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Updated: Aug 28, 2025
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Creation of a Rodent Model of Abdominal Aortic Aneurysm by Blocking Adventitial Vasa Vasorum Perfusion
Published on: November 8, 2017
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NADPH Oxidases in Aortic Aneurysms
1Department of Cardiac Surgery, Michigan Medicine, University of Michigan, Ann Arbor, MI 48109, USA.
Antioxidants (Basel, Switzerland)
|September 23, 2022
Summary
Nicotinamide adenine dinucleotide phosphate oxidase (NADPH oxidase/NOX) plays a key role in abdominal aortic aneurysm (AAA) progression. Inhibiting NOX enzymes may offer a therapeutic strategy for preventing AAA rupture.
Area of Science:
- Vascular Biology
- Biochemistry
- Pharmacology
Background:
- Abdominal aortic aneurysms (AAAs) involve aortic dilation, inflammation, and extracellular matrix degradation.
- Oxidative stress and reactive oxygen species (ROS) contribute to AAA pathogenesis, affecting smooth muscle cells and inflammatory infiltration.
- Nicotinamide adenine dinucleotide phosphate oxidase (NADPH oxidase/NOX) signaling is implicated in AAA development.
Purpose of the Study:
- To review the principles of NADPH oxidase (NOX) signaling and activation in AAAs.
- To discuss the role of NOX signaling mediators in AAA progression.
- To examine the impact of NOX inhibitors on experimental AAAs.
Main Methods:
- Review of existing literature on NOX signaling pathways in AAAs.
- Analysis of studies investigating NOX mediators and their effects.
- Evaluation of preclinical data on genetic and pharmacologic NOX inhibition in AAA models.
Main Results:
- NADPH oxidases are central to inflammatory and cellular processes in AAAs.
- Specific NOX signaling mediators significantly influence AAA development.
- Inhibition of NOX enzymes shows promise in preclinical AAA models.
Conclusions:
- NADPH oxidases are a potential therapeutic target for managing AAAs.
- Targeting NOX signaling may halt AAA progression and prevent rupture.
- Pharmacologic inhibition of NOX offers a future strategy for AAA treatment.
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