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Related Concept Videos

NF-κB-dependent Signaling Pathway02:26

NF-κB-dependent Signaling Pathway

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The transcription factor NF-κB was discovered in 1986 in the lab of Nobel laureate Professor David Baltimore, for its interaction with the immunoglobulin light chain enhancer in B-cells. After more than three decades of study, it is now evident that NF-κB regulates the expression of over 100 genes. Most of these genes play an essential role in the innate and adaptive immune responses as well as the inflammatory responses of animals.
NF-κB-dependent Signaling Mechanism
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The Intrinsic Apoptotic Pathway01:31

The Intrinsic Apoptotic Pathway

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Internal cellular stress, such as cellular injury or hypoxia, triggers intrinsic apoptosis. The B-cell lymphoma 2 (Bcl-2) family of proteins are the primary regulators of the intrinsic apoptotic pathway. For example, during DNA damage, checkpoint proteins, such as Ataxia Telangiectasia Mutated (ATM protein) and Checkpoints Factor-2 (Chk2) proteins, are activated. These proteins phosphorylate p53 which further activates pro-apoptotic proteins, such as Bax, Bak, PUMA, and Noxa, and inhibits...
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The JAK-STAT Signaling Pathway01:20

The JAK-STAT Signaling Pathway

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Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as  SH2...
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Enzyme-linked Receptors01:00

Enzyme-linked Receptors

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Enzyme-linked receptors are proteins that act as both receptor and enzyme, activating multiple intracellular signals. This is a large group of receptors that include the receptor tyrosine kinase (RTK) family. Many growth factors and hormones bind to and activate the RTKs.
Neurotrophin (NT) receptors are a family of RTKs, including trkA, trkB, and trkC (tropomyosin-related kinase) receptors. TrkA is specific for nerve growth factor (NGF), neurotrophin-6, and neurotrophin-7. TrkB binds...
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Cytotoxic T Cells-mediated Immune Response01:27

Cytotoxic T Cells-mediated Immune Response

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Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
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Cells of the Innate Immune Response01:28

Cells of the Innate Immune Response

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The innate immune response is an immediate and non-specific response against pathogens, acting swiftly to prevent the spread of infections. The primary cells involved in this response are phagocytes and natural killer (NK) cells.
Phagocytes
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Related Experiment Video

Updated: Aug 28, 2025

A Guide to Production, Crystallization, and Structure Determination of Human IKK1/α
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A Guide to Production, Crystallization, and Structure Determination of Human IKK1/α

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NFkB Pathway and Hodgkin Lymphoma.

Fabrice Jardin1

  • 1INSERM U1245, Henri Becquerel Center, IRIB, Normandy University, 76000 Rouen, France.

Biomedicines
|September 23, 2022
PubMed
Summary

Classical Hodgkin lymphoma (cHL) involves rare tumor cells with immune escape, driven by the NFkB pathway. Targeting this pathway presents therapeutic challenges but holds significant potential for treating cHL.

Area of Science:

  • Oncology
  • Molecular Biology
  • Immunology

Background:

  • Classical Hodgkin lymphoma (cHL) is characterized by rare Hodgkin and Reed-Sternberg (HRS) cells within a reactive microenvironment.
  • HRS cells exhibit a loss of B-cell markers, immune evasion, and constitutive NFkB pathway activation.
  • NFkB pathway dysregulation in cHL stems from genetic alterations, EBV infection, and microenvironmental interactions via receptors like CD30, CD40, BAFF, RANK, and BCMA.

Purpose of the Study:

  • To review the role of the NFkB pathway in classical Hodgkin lymphoma (cHL).
  • To discuss the mechanisms of NFkB pathway activation and its target genes in cHL.
  • To explore therapeutic strategies targeting the NFkB pathway in cHL.

Main Methods:

  • Literature review of studies on Hodgkin lymphoma pathogenesis.
Keywords:
Hodgkin lymphomaNFkB pathwaycfDNAtargeted therapy

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  • Analysis of molecular pathways involved in HRS cell biology.
  • Discussion of therapeutic implications of NFkB pathway targeting.

    • Main Results:

    • The NFkB pathway is constitutively activated in cHL HRS cells through various mechanisms.
    • NFkB target genes are implicated in apoptosis, proliferation, JAK/STAT signaling, B-cell marker loss, and cellular interactions.
    • Nodular predominant HL (NLPHL) exhibits a distinct NFkB signature compared to cHL.

    Conclusions:

    • The NFkB pathway is a central driver in cHL pathogenesis.
    • Targeting the NFkB pathway, directly or indirectly, offers potential therapeutic avenues for cHL.
    • Understanding the differential NFkB activation mechanisms in cHL and NLPHL is crucial for tailored treatment strategies.