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Imaging Features of Intratumoral Injection of NBTXR3 for Head and Neck Squamous Cell Carcinoma Lymph Node Metastases
Daniel Thomas Ginat1, Aditya Juloori2, Omar I Vivar3
1Department of Radiology, University of Chicago Medical Center, Chicago, IL 60637, USA.
Abstract:
NBTXR3 nanoparticle injection is a relatively novel radioenhancer for treatment of various cancers. CT scans following NBTXR3 injection of metastatic lymph nodes from head and neck squamous cell carcinoma were reviewed in a small series of patients. The radioenhancing appears as hyperattenuating, with a mean attenuation of the injected material of 1516 HU. The material was found to leak beyond the margins of the tumor in some cases.
Insights
NBTXR3 nanoparticle injection is a novel radioenhancer for cancer treatment. In head and neck cancers, CT scans showed NBTXR3 as hyperattenuating, but it sometimes leaked beyond tumor margins.
Area of Science:
- Oncology
- Nanomedicine
- Radiotherapy
Background:
- NBTXR3 is an investigational nanoparticle radioenhancer.
- It is designed to enhance the effects of radiation therapy in various cancers.
