Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Calibration Curves: Linear Least Squares01:20

Calibration Curves: Linear Least Squares

1.7K
A calibration curve is a plot of the instrument's response against a series of known concentrations of a substance. This curve is used to set the instrument response levels, using the substance and its concentrations as standards. Alternatively, or additionally, an equation is fitted to the calibration curve plot and subsequently used to calculate the unknown concentrations of other samples reliably.
For data that follow a straight line, the standard method for fitting is the linear...
1.7K
Stability of structures01:14

Stability of structures

236
In mechanical engineering, the stability of systems under various forces is critical for designing durable and efficient structures. One fundamental way to explore these concepts is by analyzing systems like two rods connected at a pivot point, O, with a torsional spring of spring constant k at the pivot point. This system is similar in appearance to a scissor jack used to change tires on a car. In this case, the arms of the linkage (equivalent to the rods in this system) are entirely vertical,...
236
One-Compartment Open Model: Wagner-Nelson and Loo Riegelman Method for ka Estimation01:24

One-Compartment Open Model: Wagner-Nelson and Loo Riegelman Method for ka Estimation

667
This lesson introduces two critical methods in pharmacokinetics, the Wagner-Nelson and Loo-Riegelman methods, used for estimating the absorption rate constant (ka) for drugs administered via non-intravenous routes. The Wagner-Nelson method relates ka to the plasma concentration derived from the slope of a semilog percent unabsorbed time plot. However, it is limited to drugs with one-compartment kinetics and can be impacted by factors like gastrointestinal motility or enzymatic degradation.
On...
667
Multicompartment Models: Overview01:14

Multicompartment Models: Overview

232
Multicompartment models are mathematical constructs that depict how drugs are distributed and eliminated within the body. They segment the body into several compartments, symbolizing various physiological or anatomical areas connected through drug transfer processes such as absorption, metabolism, distribution, and elimination.
These models offer a more comprehensive representation of drug behavior in the body than one-compartment models. They accommodate the complexity of drug distribution,...
232
Structural Classification of Joints01:20

Structural Classification of Joints

3.8K
Joints, also known as articulations, are classified based on their structural characteristics, i.e., based on whether the articulating surfaces of the adjacent bones are directly connected by fibrous connective tissue or cartilage, or whether the articulating surfaces contact each other within a fluid-filled joint cavity. These differences serve to divide the joints of the body into three structural classifications.
A fibrous joint is where the adjacent bones are united by fibrous connective...
3.8K
Multi-input and Multi-variable systems01:22

Multi-input and Multi-variable systems

143
Cruise control systems in cars are designed as multi-input systems to maintain a driver's desired speed while compensating for external disturbances such as changes in terrain. The block diagram for a cruise control system typically includes two main inputs: the desired speed set by the driver and any external disturbances, such as the incline of the road. By adjusting the engine throttle, the system maintains the vehicle's speed as close to the desired value as possible.
In the absence...
143

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Bayesian adaptation of chaos representations using variational inference and sampling on geodesics.

Proceedings. Mathematical, physical, and engineering sciences·2018
Same author

Adsorption Behavior of Ferromagnetic Carbon Nanotubes for Methyl Orange from Aqueous Solution.

Journal of nanoscience and nanotechnology·2016
Same author

The crystal structure and chemical state of aluminum-doped hydroxyapatite by experimental and first principles calculation studies.

Physical chemistry chemical physics : PCCP·2016
Same author

Opposite monosynaptic scaling of BLP-vCA1 inputs governs hopefulness- and helplessness-modulated spatial learning and memory.

Nature communications·2016
Same author

Methane limit LPS-induced NF-κB/MAPKs signal in macrophages and suppress immune response in mice by enhancing PI3K/AKT/GSK-3β-mediated IL-10 expression.

Scientific reports·2016
Same author

Branched-chain amino acid restriction in Zucker-fatty rats improves muscle insulin sensitivity by enhancing efficiency of fatty acid oxidation and acyl-glycine export.

Molecular metabolism·2016

Related Experiment Video

Updated: Aug 28, 2025

Simulation of Human-induced Vibrations Based on the Characterized In-field Pedestrian Behavior
10:52

Simulation of Human-induced Vibrations Based on the Characterized In-field Pedestrian Behavior

Published on: April 13, 2016

8.9K

Multifidelity Model Calibration in Structural Dynamics Using Stochastic Variational Inference on Manifolds.

Panagiotis Tsilifis1, Piyush Pandita1, Sayan Ghosh1

  • 1Probabilistic Design Group, General Electric Research, Niskayuna, NY 12309, USA.

Entropy (Basel, Switzerland)
|September 23, 2022
PubMed
Summary

This study introduces a stochastic variational inference algorithm to improve Gaussian process (GP) metamodeling and calibration for large datasets. The method enhances computational efficiency while maintaining Bayesian inference rigor for engineering problems.

Keywords:
Gaussian processesmanifold gradient ascentmultifidelity modelingstochastic variational inferencestructural dynamicsvibration torsion

More Related Videos

A Coupled Experiment-finite Element Modeling Methodology for Assessing High Strain Rate Mechanical Response of Soft Biomaterials
11:28

A Coupled Experiment-finite Element Modeling Methodology for Assessing High Strain Rate Mechanical Response of Soft Biomaterials

Published on: May 18, 2015

12.6K
Following the Dynamics of Structural Variants in Experimentally Evolved Populations
04:52

Following the Dynamics of Structural Variants in Experimentally Evolved Populations

Published on: February 3, 2023

1.0K

Related Experiment Videos

Last Updated: Aug 28, 2025

Simulation of Human-induced Vibrations Based on the Characterized In-field Pedestrian Behavior
10:52

Simulation of Human-induced Vibrations Based on the Characterized In-field Pedestrian Behavior

Published on: April 13, 2016

8.9K
A Coupled Experiment-finite Element Modeling Methodology for Assessing High Strain Rate Mechanical Response of Soft Biomaterials
11:28

A Coupled Experiment-finite Element Modeling Methodology for Assessing High Strain Rate Mechanical Response of Soft Biomaterials

Published on: May 18, 2015

12.6K
Following the Dynamics of Structural Variants in Experimentally Evolved Populations
04:52

Following the Dynamics of Structural Variants in Experimentally Evolved Populations

Published on: February 3, 2023

1.0K

Area of Science:

  • Engineering
  • Computational Statistics
  • Machine Learning

Background:

  • Bayesian techniques using Gaussian processes (GPs) excel at uncertainty quantification and data efficiency in engineering.
  • However, traditional GP methods face computational challenges with large datasets and numerous inputs.
  • This limits their practical application in complex engineering scenarios.

Purpose of the Study:

  • To enhance Gaussian process (GP)-based metamodeling and model calibration for large-scale engineering problems.
  • To address the computational intractability of standard GP methods with extensive training data.
  • To enable efficient and rigorous Bayesian inference in data-rich environments.

Main Methods:

  • Employed a stochastic variational inference algorithm for Gaussian process (GP) metamodeling.
  • Applied the algorithm to accelerate statistical learning of calibration parameters and hyperparameter tuning.
  • Focused on retaining the precision of Bayesian inference despite computational demands.

Main Results:

  • Demonstrated significant improvements in computational performance for GP-based tasks.
  • Successfully applied the algorithm to metamodeling and model calibration with thousands of data points.
  • Validated the method's effectiveness on multiple complex engineering problems.

Conclusions:

  • The stochastic variational inference algorithm offers a computationally efficient solution for GP metamodeling and calibration.
  • This approach makes advanced Bayesian techniques more feasible for large-scale engineering applications.
  • The method successfully balances computational speed with the rigor of Bayesian inference.