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Fitting Contralateral Neuroanatomical Asymmetry into the Amyloid Cascade Hypothesis
Fernando Arreola1, Benjamín Salazar1, Antonio Martinez2
1Programa de Ingeniería Biomédica, Universidad de Monterrey, San Pedro Garza García 66238, Mexico.
Healthcare (Basel, Switzerland)
|September 23, 2022
Summary
Asymmetry measures from MRI scans show potential as early Alzheimer's Disease (AD) biomarkers. These brain asymmetry indicators, particularly in the parahippocampal gyrus, appear earlier than traditional markers, aiding early AD diagnosis.
Area of Science:
- Neuroimaging
- Biomarker Discovery
- Neurology
Background:
- Alzheimer's Disease (AD) is the leading cause of dementia, necessitating early diagnostic methods due to its progressive neurodegeneration.
- Current diagnostic markers include cognitive function tests, cerebrospinal fluid biomarkers (Phosphorylated-Tau, Amyloid-β), and structural MRI volumetry.
Purpose of the Study:
- To evaluate the potential of asymmetry-related measures derived from MRI as early diagnostic biomarkers for Alzheimer's Disease.
- To compare the temporal evolution of these asymmetry measures against established AD diagnostic markers.
Main Methods:
- Analysis of asymmetry measures from MAPER-segmented MP-RAGE MRI data from the Alzheimer's Disease Neuroimaging Initiative (ADNI) database.
- Generation of spline regression models to analyze the temporal evolution of asymmetry measures, with data imputation for missing values.
- Comparison of temporal trends of asymmetry measures with cognitive function, tau and amyloid-β concentrations, and MRI volumetry.
Main Results:
- Regression models indicated that asymmetry measures, especially in the parahippocampal gyrus, exhibited temporal changes preceding most other evaluated biomarkers.
- This suggests asymmetry measures may serve as sensitive indicators for early-stage Alzheimer's Disease detection.
Conclusions:
- Asymmetry-related MRI measures demonstrate promise as early diagnostic biomarkers for Alzheimer's Disease.
- Further research is recommended to validate these findings and their clinical utility in early AD diagnosis.
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