Related Experiment Video
Updated: Aug 28, 2025

Author Spotlight: A Non-Intubated Video-Assisted Thoracoscopic Surgery with Multimodal Analgesia and Sevoflurane Inhalation Anesthesia
Published on: May 26, 2023
Intravenous Morphine Infusion versus Thoracic Epidural Infusion of Ropivacaine with Fentanyl after the Ravitch
Dariusz Fenikowski1, Lucyna Tomaszek1,2
1Department of Thoracic Surgery, Institute of Tuberculosis and Lung Diseases, Rabka-Zdrój Branch, 34-700 Rabka-Zdrój, Poland.
Insights
Intravenous morphine provided superior postoperative pain relief compared to thoracic epidural ropivacaine and fentanyl after the Ravitch procedure. Patients receiving morphine required less rescue medication, indicating better overall analgesia.
Area of Science:
- Pediatric Anesthesiology
- Pain Management
- Thoracic Surgery
Background:
- The Ravitch procedure, a surgical intervention for pectus excavatum, necessitates effective postoperative pain management.
- Optimizing analgesia in pediatric patients is crucial for recovery and reducing complications.
Purpose of the Study:
- To compare the efficacy of intravenous morphine infusion versus thoracic epidural infusion of ropivacaine with fentanyl for postoperative analgesia in pediatric patients undergoing the Ravitch procedure.
Main Methods:
- A comparative study involving two groups of pediatric patients: intravenous morphine infusion (n=56) and thoracic epidural ropivacaine with fentanyl (n=40).
- Pain scores (Numerical Rating Scale), rescue medication consumption, anxiety, side effects, and patient satisfaction were assessed from postoperative day 0 to day 3.
- A multimodal pain management protocol including paracetamol, NSAIDs, and metamizole as rescue was employed.
Main Results:
- Patients receiving intravenous morphine reported significantly lower average and maximal pain scores at rest, during deep breathing, and coughing compared to the epidural group (p < 0.05).
- The intravenous morphine group required significantly fewer doses of the rescue analgesic metamizole (median 1 vs. 3; p = 0.003).
- No significant differences were observed in anxiety levels, postoperative side effects, or patient satisfaction between the two groups (p > 0.05).
Conclusions:
- Intravenous morphine infusion demonstrated superior postoperative analgesia compared to thoracic epidural infusion of ropivacaine with fentanyl in pediatric patients after the Ravitch procedure.
- The findings suggest that intravenous morphine may be a more effective option for managing pain in this specific patient population.
Objective:
To compare the efficacy of analgesia with intravenous infusion of morphine and thoracic epidural infusion of ropivacaine with fentanyl in pediatric patients after the Ravitch procedure.
Methods:
Postoperative analgesia was achieved by intravenous morphine infusion with a dose of 0.02-0.06 mg/kg per hour (intravenous group, n = 56) or thoracic epidural infusion of 0.2% ropivacaine and fentanyl 5 µg/mL with a flow rate of 0.1 mL/kg per hour (epidural group, n = 40). Furthermore, the multimodal pain management protocol included paracetamol, non-steroidal anti-inflammatory drugs, and metamizole as a rescue drug. The primary outcomes included pain scores (according to the Numerical Rating Scale, range 0-10), while the secondary outcomes included consumption of the rescue drug, anxiety, postoperative side effects, and patient satisfaction. The observation period lasted from postoperative day 0 to postoperative day 3.
Results:
Median average and maximal pain scores at rest, during deep breathing, and coughing were significantly lower in the intravenous group compared to the epidural group (p < 0.05). The effect size was medium (Cohen's d ranged from 0.5 to 0.7). Patients receiving morphine required significantly lower numbers of metamizole doses than in the epidural group (median 1 vs. 3; p = 0.003; Cohen's d = 0.6). Anxiety, postoperative side effects, and patient satisfaction were similar in both groups (p > 0.05).
Conclusions:
An intravenous infusion of morphine may offer better postoperative analgesia than a thoracic epidural infusion of ropivacaine with fentanyl.
Related Concept Videos
Local Anesthetics: Clinical Application as Epidural Anesthesia
Since epidural anesthetics can be infused through an epidural catheter, all types of drugs, including short-acting ones, can be administered. Chloroprocaine and lidocaine are examples of short and long-duration anesthetics, respectively. Bupivacaine...
Parenteral Anesthetics: Overview
Opioid Analgesics: Synthetic and Semisynthetic Opioids
Local Anesthetics: Clinical Application as Intravenous Regional Anesthesia
One of the advantages of...
Opioid Analgesics: Morphine and Other Natural Cogeners
Local Anesthetics: Clinical Application as Spinal Anesthesia

