The Effects of Short-Term PM_2.5 Exposure on Pulmonary Function among Children with Asthma-A Panel Study in Shanghai,...

Fine particulate matter (PM_2.5) has been reported to be an important risk factor for asthma. This study was designed to evaluate the relationship between PM_2.5 and lung function among children with asthma in Shanghai, China. From 2016 to 2019, a total of 70 Chinese children aged 4 to 14 in Shanghai were recruited for this panel study. The questionnaire was used to collect baseline information, and the lung function covering forced vital capacity (FVC), forced expiratory volume in 1 s (FEV1) and peak expiratory flow (PEF) were carried out for each child more than twice during follow-up. Meanwhile, the simultaneous daily air atmospheric pollutants and meteorological data were collected. The linear mixed effect (LME) model was used to assess the relationship between air pollutants and lung function. A significantly negative association was found between PM_2.5 and lung function in children with asthma. In the single-pollutant model, the largest effects of PM_2.5 on lung function were found for lag 0-2, with FVC and FEV1 decreasing by 0.91% [95% confidence interval (CI): -1.75, -0.07] and 1.05% (95% CI: -2.09, 0.00), respectively, for each 10 μg/m³ increase in PM_2.5. In the multi-pollution model (adjusted PM_2.5 + SO₂ + O₃), the maximum effects of PM_2.5 on FVC and FEV1 also appeared for lag 0-2, with FVC and FEV1 decreasing by 1.57% (95% CI: -2.69, -0.44) and 1.67% (95% CI: -3.05, -0.26), respectively, for each 10 μg/m³ increase in PM_2.5. In the subgroup analysis, boys, preschoolers (<6 years old) and hot seasons (May to September) were more sensitive to changes. Our findings may contribute to a better understanding of the short-term exposure effects of PM_2.5 on lung function in children with asthma.