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The Role of Matrix Metalloproteinase in Inflammation with a Focus on Infectious Diseases

Han Sol Lee1, Woo Joo Kim1,2

  • 1Asia Pacific Influenza Institute, Korea University College of Medicine, Seoul 02841, Korea.

International Journal of Molecular Sciences
|September 23, 2022
PubMed

Insights

Matrix metalloproteinases (MMPs) regulate inflammation and extracellular matrix remodeling, impacting diseases. This review explores their role in infectious diseases and potential as therapeutic targets.

Area of Science:

  • Biochemistry
  • Immunology
  • Pathology

Background:

  • Matrix metalloproteinases (MMPs) degrade extracellular matrix components and modulate inflammatory cytokines like TNF-α and IL-1β.
  • Dysregulation of MMPs and inflammatory responses are implicated in lung and cardiovascular diseases.
  • MMPs play a role in infectious disease pathogenesis via altered activity and expression.

Purpose of the Study:

  • To review the role of MMPs in infectious diseases and inflammatory responses.
  • To highlight the potential of MMPs as therapeutic targets for infectious diseases.

Main Methods:

  • Literature review of studies on MMPs in infectious diseases and inflammation.
  • Analysis of MMPs' involvement in disease pathogenesis.
  • Evaluation of MMPs as therapeutic targets.

Main Results:

  • MMPs are crucial in extracellular matrix remodeling and inflammatory processes.
  • Altered MMP activity and expression contribute to infectious disease development.
  • MMPs influence the pathogenesis of various diseases.

Conclusions:

  • MMPs are key players in infectious diseases and inflammation.
  • Targeting MMPs offers a promising therapeutic strategy for infectious diseases.
Keywords:
SARS-CoV-2infectious diseasesinfluenza A virusmatrix metalloproteinases

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